the forced degradation study of lidocaine hcl was carried out according to the ich guideline q1a (r2). the degradation conditions were assessed to be hydrolysis, oxidation, photolysis and dry heat during 24 h, 48 h and 72 h and then the samples were investigated by gc-fid method and nuclear magnetic resonance (nmr) spectroscopy. according to these results, the degradation products were not obse...

BACKGROUND Mosaicism and hyperinflation are common pathophysiologic features of bronchiectasis. The magnitude of ventilation heterogeneity might have been affected by the degree of hyperinflation. Some studies have evaluated the discriminative performance of lung clearance index (LCI) in bronchiectasis patients, but the additive diagnostic value of hyperinflation metrics to LCI is unknown. OB...

RATIONALE Mitochondrial-derived hydrogen peroxide (H2O2) regulates flow-induced dilation (FID) in microvessels from patients with coronary artery disease. The relationship between ceramide, an independent risk factor for coronary artery disease and a known inducer of mitochondrial reactive oxygen species, and FID is unknown. OBJECTIVE We examined the hypothesis that exogenous ceramide induces...

BACKGROUND Urinary organic acids are water-soluble intermediates and end products of the metabolism of amino acids, carbohydrates, lipids, and a number of other metabolic processes. In the hereditary diseases known as organic acidurias, an enzyme or co-factor defect in a metabolic pathway leads to the accumulation and increased excretion of one or more of these acidic metabolites. Gas chromatog...

ginger plant, zingiber officinale roscoe, is an important tropical plant used as spices and well known for its medicinal properties. it has a pungent and aromatic rhizome rich of zingiberen and gingerols. many secondary metabolites are known to accumulate in the plant cell culture systems. so, in this research, gingerols and zingiberene production of callus cultures were compared with regenerat...

background:the present study aims to present a new method to trace narcotics in the solution extracted from dried urine stain left on cotton fabric. material and methods:narcotic substance was traced in the 50 samples through two methods. in the first method, samples were directly examined through thin layer chromatography (tlc). in the second method, a piece of cotton fabric was soaked in a be...

The Single Point Ramped Imaging with T1 Enhancement (SPRITE) sequence is well suited for the acquisition of magnetic resonance signals from fast relaxing nuclei and from heterogeneous materials. However, it is time inefficient compared to sequences that are based on frequency encoding because only one single point is acquired per excitation. Multiple-point SPRITE (mSPRITE) mitigates this proble...

Abstract Funding Acknowledgements Type of funding sources: Private grant(s) and/or Sponsorship. Main source(s): Stiftung KinderHerz Weserstr. 101 45136 Essen. Background For the last decades, surgical progress lead to better functional outcomes in patients with congenital heart defect (CHD), which may also affect lung function. Reduced volumes were found about half all a CHD. Purpose This prosp...