نتایج جستجو برای: tissue tropism
تعداد نتایج: 921469 فیلتر نتایج به سال:
The binding of viruses to host cells is the first step in determining tropism and pathogenicity. While avian infectious bronchitis coronavirus (IBV) infection and avian influenza A virus (IAV) infection both depend on α2,3-linked sialic acids, the host tropism of IBV is restricted compared to that of IAV. Here we investigated whether the interaction between the viral attachment proteins and the...
Since April 2012, there have been 17 laboratory-confirmed human cases of respiratory disease associated with newly recognized human betacoronavirus lineage C virus EMC (HCoV-EMC), and 7 of them were fatal. The transmissibility and pathogenesis of HCoV-EMC remain poorly understood, and elucidating its cellular tropism in human respiratory tissues will provide mechanistic insights into the key ce...
CB # 7352, Gene Therapy Center, 5123 Thurston Building 16 The University of North Carolina at Chapel Hill 17 Chapel Hill, NC 27599-7352 18 Tel. No: 919-843-7621 19 Fax No: 919-966-0907 20 Email: [email protected] 21 22 Running Title: Tissue glycans drive AAV9 tropism 23 Abstract: 218 24 Main text: 8062 25 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Virol. doi:...
BACKGROUND Highly pathogenic avian H5N1 influenza viruses preferentially infect alveolar type II pneumocytes in human lung. However, it is unknown whether this cellular tropism contributes to high viral virulence because the primary target cells of other influenza viruses have not been systematically studied. METHODS We provide the first comparison of the replication, tropism, and cytokine in...
Primary systemic amyloidosis (AL) is a protein conformation disorder in which monoclonal immunoglobulin light chains produced by clonal plasma cells are deposited as amyloid in the kidneys, heart, liver, or other organs. Why patients with AL present with amyloid disease that displays such organ tropism is unknown. This study tested the hypothesis that both the light-chain variable region (Ig V(...
Many animal models of bacterial diseases are hampered by differences in tissue tropism and the course of pathogenesis. In a recent issue of Cell, by rationally mutating a surface invasion protein (InlA) to have higher binding affinity for its cognate host receptor (E-cadherin), Wollert et al. were able to "murinize"Listeria monocytogenes, creating a strain capable of invading intestinal epithel...
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