نتایج جستجو برای: timp2
تعداد نتایج: 338 فیلتر نتایج به سال:
Matrix metalloproteinases (MMPs) are a family of multidomain enzymes involved in the physiological degradation of connective tissue, as well as in pathological states such as tumor invasion and arthritis. Apart from transcriptional regulation, MMPs are controlled by proenzyme activation and a class of specific tissue inhibitors of metalloproteinases (TIMPs) that bind to the catalytic site. TIMP...
BACKGROUND Previous cross-sectional studies have suggested that biomarkers of extracellular matrix remodelling are associated with atrial fibrillation (AF), but no prospective data have yet been published. Hence, we examine whether plasma matrix metalloproteinases (MMP) and their inhibitors are related to increased risk of incident AF. METHODS We used a case-cohort design in the context of th...
Tissue inhibitors of metalloproteinases (TIMPs), the endogenous inhibitors of matrix metalloproteinases, have been shown to possess biological functions that are independent of their ability to inhibit matrix metalloproteinases. We have previously shown that the C-terminal domain of TIMP-2 and, in particular, Loop 6 inhibit capillary endothelial cell proliferation and angiogenesis both in vitro...
Pleomorphic adenoma (PA) is the most common neoplasm of salivary glands and consists epithelial mesenchymal components. Although a benign lesion, it harbors potential for recurrence malignant transformation. Also, due to its histological diversity unpredictive behavior PA can represent both diagnostic therapeutic challenge. Matrix metalloproteinases (MMPs) are well known modifiers extracellular...
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