background:the door-to-needle-time (dnt) is considered a standard time for scheduling thrombolysis for acute st-segment elevation of myocardial infarction and this time can be reduced by minimizing the delay in starting thrombolytic treatment once the patient has reached to the hospital. this study was carried out on a sample of iranian patients with acute myocardial infarction to determine the...

Runoff leads to the leaching of soil nutrients, transports the topsoil particles and deposits the sediments in water reservoirs. Recognition of different environmental factors affecting the runoff properties and water infiltration depth has a great importance concerning soil for the integrated management of watershed and the distinguishment of complex hydrological processes. Thus, this research...

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Tissue Plasminogen Activator and Time to Treatment The National Institute of Neurological Disorders and Stroke studies, published in 1995, demonstrated for the first time that in patients selected by clinical and noncontrast computed tomography criteria, intravenous TPA (IV tissue plasminogen activator) resulted in improved outcomes compared with standard treatment. Since that time, safe and qu...

Joanna Moncrieff looks at the lack of long-term evidence for antipsychotic medication and considers what is needed to ensure we have the knowledge to maximize benefits and minimize harms.

n engl j med 369;10 nejm.org september 5, 2013 889 20 to 30 minutes of ischemia, it takes several hours for transmural myocardial necrosis to develop. The goal of reperfusion therapy with fibrinolytic drugs or primary percutaneous coronary intervention (PCI) is to restore blood flow to ischemic, but still viable, myocardium and reduce infarct size. Reducing the time to treatment and maximizing ...