the purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. polyethylene oxide (peo) and hydroxypropyl methylcellulose (hpmc) were evaluated for matrix-forming properties. a simplex lattice design was applied to systemically optimize the drug release profile. the amounts of peo wsr 303, hpmc k15m and sodium bicarbonate were selected as independen...

In many cases, redundant systems are beset by both independent and dependent failures. Ignoring dependent variables in MTBF evaluation of redundant systems hastens the occurrence of failure, causing it to take place before the expected time, hence decreasing safety and creating irreversible damages. Common cause failure (CCF) and cascading failure are two varieties of dependent failures, both l...

Lead time is one of the major limits that affect planning at every stage of the supply chain system. In this paper, we study a continuous review inventory model. This paper investigates the ordering cost reductions are dependent on lead time. This study addressed two-echelon supply chain problem consisting of a single vendor and a single buyer. The main contribution of this study is that the in...

introduction compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents. in this study, we aimed to develop a pharmacokinetic model of 153sm-maltolate complex as a novel therapeutic agent and...

In the traditional cost-efficiency model, the information about each decision unit includes inputs, outputs, and the input prices are fixed and specific. In practice, the price of the inputs often fluctuates at different times, and these prices for the decision-making unit are time-dependent. By the traditional method, the efficiency of decision units is impossible in the presence of time-depen...

in this paper, optimal distributed control of the time-dependent navier-stokes equations is considered. the control problem involves the minimization of a measure of the distance between the velocity field and a given target velocity field. a mixed numerical method involving a quasi-newton algorithm, a novel calculation of the gradients and an inhomogeneous navier-stokes solver, to find the opt...

In this paper the authors consider the continuous deterministic, infinite horizon, single item inventory system within the setting of a retailer sector in which the demand rate for an item is time dependent. The parameter of the replenishment cost is kept constant, but the carrying cost per unit is allowed to vary. The optimal policies are found, and decision rules and classical EOQ model have ...