BACKGROUND The purpose of this study was to assess the safety and efficacy of fixed-combination brinzolamide 1%/timolol 0.5% (BRINZ/TIM-FC) compared with concomitant brinzolamide 1% and timolol 0.5% (BRINZ + TIM) in Japanese patients with open-angle glaucoma (primary open-angle, exfoliation, pigmentary) or ocular hypertension. METHODS This randomized, double-masked, multicenter, parallel-grou...

Engulfment of apoptotic cells is an active process coordinated by receptors on phagocytes and ligands on apoptotic cells [1]. Phosphatidylserine (PtdSer) is a key ligand on apoptotic cells, and recently three PtdSer recognition receptors have been identified, namely, TIM-4, BAI1, and Stabilin-2 [1-6]. Whereas BAI1 is dependent on the ELMO1/Dock180/Rac signaling module, and Stablilin-2 appears t...

Due: Thursday Dec 14, 2006 Late penalties: The term ends on Dec 15, 2006. If you have not completed this assignment by the 14th, you may hand it in on the 15th to the Gatsby Unit (4th floor either Alexandra Boss or Rachel Howes) with a 5% penalty. After that, all assignments handed in by Friday Jan 12, 2006 will receive a fixed 30% penalty. Anything submitted after Jan 12th will not be marked a...

During pregnancy, CD8+ T cells are important regulators in the balance of fetal tolerance and antiviral immunity. T-cell immunoglobulin mucin-3 (Tim-3) and programmed cell death-1 (PD-1) are well-recognized negative co-stimulatory molecules involved in viral persistence and tumor metastasis. Here, we demonstrate that CD8+ T cells co-expressing Tim-3 and PD-1 were down-regulated in the deciduae ...

Abstract Tim-3/Gal-9 and the NLRC4 inflammasome contribute to glioma progression. However, underlying mechanisms involved are unclear. Here, we observed that expression increased with malignancy found regulate formation activation. inflammasome-related molecule levels WHO grade, this association was correlated low survival. We investigated by genetically regulating Tim-3 its ligand Gal-9. regul...

CD8+ alloreactive T cells are the key mediators of accelerated rejection. Vigorous CD8+ alloreactive T cells responses against alloantigens, which is the main effector mechanism in acute allograft rejection, has been well described. But the molecular mechanisms to dampen activated CD8+ T cells are largely unknown. On the other hand, Tim-3 is a molecule expressed on terminally differentiated CD4...