نتایج جستجو برای: thyroid tumors
تعداد نتایج: 255683 فیلتر نتایج به سال:
We report two familial adenomatous polyposis (FAP) kindreds with thyroid cancer, harboring two apparently novel germlineAPC mutations. The clinical phenotype in the first kindred was typical of classical adenomatous polyposis, whereas the second kindred exhibited an attenuated adenomatous polyposis phenotype. There was a female predominance with a mean age of 34 years (range, 23-49) at cancer d...
CONTEXT Pituitary tumor-transforming gene (PTTG) is a multifunctional protein involved in several tumorigenic mechanisms, including angiogenesis. PTTG has been shown to promote angiogenesis, a key rate-limiting step in tumor progression, by up-regulation of fibroblast growth factor-2 and vascular endothelial growth factor. OBJECTIVE To investigate whether PTTG regulates other angiogenic genes...
Follicular cell-derived well-differentiated thyroid cancer, papillary (PTC) and follicular thyroid carcinomas comprise 95% of all thyroid malignancies. Familial follicular cell-derived well-differentiated thyroid cancers contribute 5% of cases. Such familial follicular cell-derived carcinomas or non-medullary thyroid carcinomas (NMTC) are divided into two clinical-pathological groups. The syndr...
Continuous development of oncology as a science in the last decades and years led to noticeable improvement treatment outcomes for patients with various malignant tumors. Diagnostics, surgery, radiotherapy significantly contributed this improvement, however they cannot be compared progress achieved through advancements our knowledge genetic structure tumors subsequent pharmacology which allowed...
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