Platelet monoamine oxidase (MAO) activity and serum thyroxine indices were determined in 62 children and adolescents currently undergoing medical treatment for various thyroid disorders. The platelet MAO activity of these patients was similar to that of control and contrast groups previously reported, and there were no differences when patients were grouped according to specific thyroid disorde...

Background: Cancer cells have to take metabolic transformation in tumor progression when facing need of increased energy and adequate vascularization. However, molecular mechanism is not fully known. In this study, we showed that expression of carnitine palmitoyltransferase 1C (Cpt1c), as a member of the gate-keeper enzymes , which transferring long-chain fatty acids into mitochondria to furthe...

Nitrate is a wide spread contaminant of ground and surface water. The source of nitrate in the ground water may be from run off or seepage from fertilized soil, municipal or industrial waste water, land fills, septic system, urban drainage or decaying plants. Human and animal systems are affected severely on nitrate exposure. The study was to investigate the effect of dietary nitrate exposure o...

OBJECTIVE To evaluate alterations in ligand-stimulated activity of G proteins in thyroid gland cells of hyperthyroid cats. SAMPLE POPULATION Membranes of thyroid gland cells isolated from 5 hyperthyroid cats and 3 age-matched euthyroid (control) cats immediately after the cats were euthanatized. PROCEDURES Isolated thyroid cell membranes were treated with thyroid-stimulating hormone (TSH), ...

The effects of aging on human or animal thyroid function are still not well defined. We evaluated some aspects of thyroid function during aging using an animal model (young and old Dutch-Miranda rats). In old rats of both genders, serum thyroxine (T4) decreased but serum thyrotrophin (TSH) remained unaltered, suggesting a disturbance in the pituitary-thyroid feedback mechanism during aging. Ser...

In rats, various growth factors and hormones, as well as partial hepatectomy (PH) are able to trigger the proliferative response of hepatocytes. Although recent evidence highlights the important role of thyroid hormones and thyroid status in regulating the growth of liver cells in vitro and in vivo models, the mechanism involved in the pro-proliferative effects of thyroid hormones is still uncl...

Thyroid hormone is indispensable for normal development and metabolism of most cells and tissues. Thyroid hormones are metabolized by different pathways: glucuronidation, sulfation, and deiodination, the latter being the most important. Three enzymes catalyzing deiodination have been identified, called type 1 (D1), type 2 (D2) and type 3 (D3) iodothyronine deiodinases. D1 and D2 have outer ring...

T HE exposure of most warm blooded animals to a cold environment gives rise to a number of apparently related metabolic phenomena. An increase in metabolic rate as measured by oxygen consumption, takes place very rapidly and in the rat at a temperature just above freezing; the rate may reach a level two or three times that observed at the critical temperature of the animal (I, 2). When exposure...

Objective: The copper-zinc superoxide dismutase gene resides on chromosome 21 and is over expressed in Down syndrome patients. Reactive oxygen species can initiate lipid peroxidation and DNA damage leading to mutagenesis, carcinogenesis and cell death, if the antioxidant system is impaired. Down syndrome is associated with various forms of thyroid dysfunction, hypothyroidism being the most comm...

Formaldehyde (HCHO) exposure in industry causes health impairment, especially immune profile. Male albino rats when exposed to HCHO at 5, 10, 15 mg/kg day for 30 days showed decrease in thyroid weight in 10, 15 mg/kg/day HCHO fed group with commensurate follicular regression (epithelial cells), decreased triiodothyronine (T3), thyroxin (T4) deficiency and enhanced thyroid stimulating hormone (T...