نتایج جستجو برای: thrombomodulin
تعداد نتایج: 1700 فیلتر نتایج به سال:
Takotsubo (TTS) syndrome is an acute cardiac condition characterized by transient and reversible left ventricle dysfunction that mainly affects postmenopausal women. Catecholamine burst the most accredited mechanism underpinning TTS onset leading to endothelial platelet activation. Even if use of low dose acetylsalycilic acid (ASA) in this clinical setting based on both presentation unfavorable...
Quiescent endothelial cells (EC) regulate blood flow and prevent intravascular thrombosis. This latter effect is mediated in a number of ways, including expression by EC of thrombomodulin and heparan sulfate, both of which are lost from the EC surface as part of the activation response to proinflammatory cytokines. Loss of these anticoagulant molecules potentiates the procoagulant properties of...
Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal injury. Thrombomodulin is a necessary factor in the anticoagulant protein C pathway and has inherent anti-inflammatory properties. We studied the effect of soluble thrombomodulin (sTM) in a hypoperfusion model of ischemic kidney injury. To markedly reduce infrarenal aortic blood flow and femoral arterial press...
Abstract Background and Aims Non-alcoholic fatty liver disease (NAFLD) is associated with endothelial dysfunction which a common problem in hemodialysis patients risk for high cardiovascular mortality hemodialysis. Thrombomodulin promising marker of cell injury different pathological conditions. This study evaluates the additive effect non-alcoholic prevalent HD on dysfunction. Methods A case-c...
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