Intracranial hemorrhage is a rare devastating complication of idiopathic thrombocytopenic purpura (ITP), mostly presenting as intraparenchymal or subarachnoid haemorrhage. Isolated chronic subdural haematoma (SDH) is still very rare and the optimal management is unsettled. Spontaneous resolution of chronic SDH in patients with idiopathic thrombocytopenic purpura is possible. We report a case of...

A 39 year old woman presented with a short history of bloody diarrhoea. She subsequently developed microangiopathic haemolysis, platelet consumption, and renal impairment. Initial investigations suggested underlying Crohn's disease of the terminal ileum complicated by sepsis and disseminated intravascular coagulation. However, after resection of a perforated caecum and terminal ileum, the diagn...

Platelet transfusions can be lifesaving for neonates with thrombocytopenic hemorrhage. However, multiple themselves convey risks and hazards. We cared a preterm neonate severe/prolonged acquired thrombocytopenia who received 61 platelet transfusions. Her counts stabilized, further were not needed, following three escalating doses of romiplostim.

Autoimmune diseases may be related with the development of a secondary autoimmune disorder. We, herein, report a case (31 years old female) of idiopathic thrombocytopenic purpura responding to antithyroid treatment in a patient with Graves Opthalmopathy (GO). The relation between Idiopathic Thrombocytopenic Purpura (ITP) and Graves Disease (GD) is not well known. In the current case, recovery f...

With the technical assistance of \Iiss MAuIIEEN JENNER T HERE IS now considerable evidence to suggest that the hemorrhagic manifestations of thrombocytopenic purpura and certain other disorders are probably due largely to deranged platelet function rather than to a reduction in platelet numbers. It is, of course, true that associated vascular changes also play an important role in thrombocytope...

in systemic lupus erythematosus- (sle) various antibodies are produced against cells including platelets and result in thrombocytopenia. in the literature, the incidence of thrombocytopenia varied from 7% to 52%, in seven series of sle patients with a mean cumulative percentage of 14.5% (1-5). sle patients referred to the lupus unit of the rheumatology research center, tehran university for med...

T HE OPPORTUNITY presented itself recently for the study of a case of chronic idiopathic thrombocytopenic purpura characterized by the presence of unusually large agranular platelets. Several features indicated that the platelets were physiologically defective and led to the diagnosis of a thrombopathic or thrombasthenic type of thrombocytopenic purpura. When a blood transfusion from a polycyth...

Thrombotic thrombocytopenic purpura (TTP) is a rare disorder belonging to thrombotic microangiopathies (TMA) and is caused by functional deficiency of the ADAMTS-13 metalloproteinase. Plasma exchange (PE) remains the treatment of choice in this disease. Here, were describe the case of a patient who apparently recovered from TTP following multiple sessions of PE, but remained thrombocytopenic. C...

Although it is widely accepted that patients with immune thrombocytopenia produce platelet antibodies, the demonstration of such antibodies has been difficult and time consuming. A simple and quick enzyme linked immunoassay for platelet antibodies is presented. The platelet associated IgG is coupled with alkaline phosphatase labeled anti-IgG. The resultant complex is determined spectrophotometr...

Six patients had serious complications as consequences of treatment of idiopathic thrombocytopenic purpura. Five had splenectomy-related complications, one of them developed fatal intra-abdominal bleeding. Three patients acquired operation-related serious infection, two of them died. Serious neutropenia after vinblastine-loaded platelets occurred in one patient leading to pseudomonas septicaemi...