Background: Colorectal cancer is responsible for 10% of cancer related deaths and is the third most common cancer type in men and the second in women. Metastatic disease will develop in nearly 60% of patients with colorectal cancer, half of which will be located in the liver. At least 30% of the patients who underwent potentially curative primary tumor resection have liver micrometastases. Data...

objectives the aim of this study was to evaluate the efficacy, safety, and tolerability of sofosbuvir and ribavirin in ldlt recipients with recurrent hcv genotype 4. patients and methods thirty-nine egyptian ldlt recipients were treated for recurrent hcv after ldlt with nucleos(t)ide analog ns5b polymerase inhibitor, sofosbuvir, and ribavirin without pegylated interferon for 6 months (november ...

cobalt is an essential co-factor in red blood cell production and function and its deficiency may produce clinical signs in sheep. thus, present study was designed to evaluate the effect of cobalt nano-particles on serum biochemical factors and histopathological changes in liver and kidnies of lambs. study was carried out in 3 groups of lambs (4 lambs per group). one group of lambs was kept as ...

Glutamine synthetase and glutaminase activities in human cirrhotic liver tissues and hepatocellular carcinomas were determined for comparison with normal liver tissues. In hepatocellular carcinoma, glutamine synthetase activity was approximately one-third of that in normal liver, whereas no detectable change in the enzyme activity was observed in cirrhotic liver. Phosphate-dependent and phospha...

Food induced sensitization has been reported in pediatric liver recipients. However long term follow up has not been established so far.We report here our experience regarding 3 pediatric patients who developed acquired food allergy after liver transplantation. The first patient suffered from persistent diarrhea and eczema. The second one presented with abdominal pain with no signs of rejection...

Voluntary overfeeding rapidly induces resistance to the effects of systemic insulin and leptin on liver glucose metabolism. To examine whether central administration of recombinant leptin can restore leptin and insulin action on liver glucose fluxes, we infused leptin in the third cerebral ventricle of conscious overfed rats during pancreatic-insulin clamp studies. The effect of leptin on the p...

Paclitaxel has been shown to have clinical activity in the treatment of small cell lung cancer (SCLC). However, its role as third-line chemotherapy for SCLC after both etoposide- and camptothecin-based regimens has not been clarified.All patients with refractory SCLC who were treated with paclitaxel-based regimen as third-line chemotherapy between 2005 and 2011 in Seoul National University Bund...

The technique of stem cells or hepatocytes transplantation has recently improved in order to bridge the time before whole-organ liver transplantation. In the present study, unfractionated bone marrow stem cells (BMSCs) were harvested from the tibial and femoral marrow compartments of male mice, which were cultured in Dulbecco's modified Eagle's medium (DMEM) with and without hepatocyte growth f...