Treatment of poliovirus Type I with 10(-3)m 2-thiouracil (2-TU) resulted in the inactivation of greater than 90% of the virus infectivity and stabilization of approximately 50% of the residual virus to heat inactivation. These effects were due to a reaction with the protein moiety of the virus and could be blocked by pre-treatment of the virus with l-cystine or of the drug with cysteine. Both i...

The morphology of the tight junction of rat thyroid epithelium was examined in freeze-fractured material fixed in glutaraldehyde and briefly glycerinated. In normal thyroids the overall appearance of this junctional specialization resembled that of other cell types in many respects. Short-term changes in thyroid activity and hypophysectomy for 3 wk did not obviously affect the appearance of t...

THE main pathway of cholesterol catabolism involves the conversion of cholesterol to bile acids which are eliminated via the bile and feces. As liver cholesterol is considered to exist in equilibrium with serum cholesterol, nutritional factors accelerating cholesterol catabolism may lower the serum cholesterol level. Furthermore, it is well known that hypercholesterolemia and subsequent experim...

Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diff...

Electrochemical oxidation of the catechols 1a and 1b is studied in the presence of 6-methyl-2-thouracil (3b) and 6-propyl-2-thiouracil (3a) as nucleophiles in a phosphate buffer (0.15 mol L−1, pH = 6.8)/DMF (95:5) solution using cyclic voltammetry and controlled-potential coulometry. The results obtained indicate that the quinones derived from the catechols participate in 1,4-Michael-addition r...

Bromide and thiocyanate have been shown to be effective inhibitors of the chlorination process leading to chlortetracycline formation by certain strains of Streptomyces aureofaciens Duggar (Gourevitch et al., 1955; Doerschuk, et at., 1956). Sekizawa (1955) reported thiourea, 2-thiouracil, 2-mercaptobenzothiazole, and thioglycolic-f3-aminonaphthalide (thionalide) to inhibit chlorination by this ...