Previous investigations with a spectrum of tu mors demonstrated that nitrogen mustards (17) and triethylene melamine (19) had a definite in hibitory or destructive action on certain types of tumors. In view of the fact that the biological ac tivity of these compounds is believed to be due to the formation of ethylenimmonium ions in the case of the former (7) and the presence of ethylenimine gro...

In the title thio-cyanate-coordinated aza-macrocyclic copper(II) complex, [Cu(NCS)(2)(C(24)H(38)N(6))], the Cu(II) atom is coordinated by the four secondary N atoms of the aza-macrocyclic ligand and by the two N atoms of the thio-cyanate ions in a tetra-gonally distorted octa-hedral geometry. The average equatorial Cu-N bond length is shorter than the average axial Cu-N bond length [2.010 (2) a...

The clinical use of alkylating drugs represents an important contribution toward the chemotherapeutic management of certain forms of human cancer. Several recent reports summarize the palliative responses obtained with triethylenemelamine (TEM), triethylene phosphoramide (TEPA), and Myleran (Busulfan) in patients with malignant neoplasias of lymphatic or myelogenous origin (2, 3, 11, 12). The c...

In this essay we address the puzzle that exists in American politics based on the tension of convergence to the electoral mean because of the MVT (mean voter theorem) and the studies showing divergence in candidate positioning.We provide amodel in which voters and states are not treated equally because of vast regional differences. In contrast with the MVT, candidates who campaign in each state...

This second of two articles on the ‘typical’ (‘ first-generation’) anti psychotics covers nonphenothiazines: thio xan thenes (flupentixol and zuclo penthixol), butyro phenones/diphenyl butylpiperidines (including one-time world marketleader haloperidol, and pimozide) and sulpiride, for many years the only substituted benzamide available in the UK. Several tolerability issues ascribed specifical...

English] Teams distributed across cultural, geographic and temporal boundaries, also known as multicultural virtual teams (MVTs), have been prevalent in international organizations. To provide guidance for MVT managers and support accumulation of prior experience, we establish a management model based on the extended adaptive structuration theory (EAST) and verify the model with 55 empirical st...

Ketamine is primarily metabolized to norketamine by hepatic CYP2B6 and CYP3A4-mediated N-demethylation. However, the relative contribution from each enzyme remains controversial. The CYP2B6*6 allele is associated with reduced enzyme expression and activity that may lead to interindividual variability in ketamine metabolism. We examined the N-demethylation of individual ketamine enantiomers usin...

A comparison was made of 14C-leucine incorporation and cell viability of T24 human bladder carcinoma cells after treatment with Thio-Tepa, a potent alkylating agent. It was found that Thio-Tepa produced concentration-dependent damage in these cells and also that 14C-leucine incorporation correlated well with cell viability. 14C-leucine incorporation can be used as a reliable and rapid screening...