Considerable advances have been made in recent vears in the use of chemotherapy in tuberculosis. WVhile alterations in technique are constantly under review the following summarises the present position. Combinations of drugs and treatment schedules that combine maximum benefit with minimal drug toxicity and bacterial resistance, have been the object in much research all over the world. The dru...

An extensive literature has developed in recent years in the field of chelate compounds with special reference to their antimicrobial properties. Thus, for example, the copper chelate of oxine (8-hydroxyquinoline) has been the subject of numerous investigations (Hollingshead, 1956). Thiosemicarbazones (TSC), which are compounds capable of forming chelates, have been investigated by Domagk (1950...

SUMMARY 2-F o rmylpy rid i ne thiosemicarbazone (PT), 3-hydroxy-2-formylpyridine thiosemicarbazone (3-HP), and 5-hydroxy-2-formylpyridine thiosemicarbazone (5-HP) are potent inhibitors of the growth of Sarcoma 180 ascites cells. PT is quite toxic to the tumor-bearing host and does not markedly extend the lifespan of mice bearing Sarcoma 180; however, the therapeutic potential of 3-1-IP and 5-HP...

Small-molecule restoration of wild-type structure and function to mutant p53 (so-called mutant reactivation) is a highly sought-after goal in cancer drug development. We previously discovered that small-molecule zinc chelators called zinc metallochaperones (ZMCs) reactivate mutant p53 by restoring zinc binding to zinc-deficient p53 mutants. The lead compound identified from the NCI-60 human tum...

Thiosemicarbazone analogs of papaveraldine and related compounds 1-6 were synthesized and evaluated for cytotoxic and antimalarial activities. The cytotoxic activity was tested against HuCCA-1, HepG2, A549 and MOLT-3 human cancer cell lines. Thiosemicarbazones 1-5 displayed cytotoxicity toward all the tested cell lines, while compounds 2-5 selectively showed potent activity against the MOLT-3 c...

Isatin is an endogenous compound identified in humans that possesses a wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activities and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES, scPTZ and scSTY tests. Various isatin-N-Mannich bases of ...