نتایج جستجو برای: thiopurine methyl transferase
تعداد نتایج: 139474 فیلتر نتایج به سال:
Cephalosporin antibiotics with structures that include the heterocyclic leaving group 1-methyltetrazole-5-thiol (MTT) can cause hypoprothrombinemia and hemorrhage as a result of MTT-dependent inhibition of the gamma-carboxylation of glutamate. The structure of cefazolin also includes a heterocyclic thiol, 2-methyl-1,3,4-thiadiazole-5-thiol (MTD), and this compound can also inhibit the gamma-car...
Dishevelled, a phosphoprotein scaffold, is a central component in all the Wnt-sensitive signaling pathways. In the present study, we report that Dishevelled is post-translationally modified, both in vitro and in vivo, via arginine methylation. We also show protein arginine methyl transferases 1 and 7 as the key enzymes catalyzing Dishevelled methylation. Interestingly, Wnt3a stimulation of F9 t...
The demonstration of the hormone mclatonin (N-acetyl-Bmethoxytryptamine) in bovine pineal gland (1) prompted a study of the enzymes involved in its formation and metabolism. In preliminary studies (2, 3) we described an enzyme, hydroxyindole-O-methyl transferase, in the pineal gland of cows, that catalyzes the 0-methylation of N-acetyl-serotonin to melatonin. This paper describes the purificati...
Thiopurine methyltransferase (TPMT) activity exhibits monogenic co-dominant inheritance, with ethnic differences in the frequency of occurrence of variant alleles. With conventional thiopurine doses, homozygous TPMT-deficient patients (~1 in 178 to 1 in 3,736 individuals with two nonfunctional TPMT alleles) experience severe myelosuppression, 30-60% of individuals who are heterozygotes (~3-14% ...
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