Myosin binding protein-C (MyBP-C) is a key regulatory protein in heart muscle, and mutations in the MYBPC3 gene are frequently associated with cardiomyopathy. However, the mechanism of action of MyBP-C remains poorly understood, and both activating and inhibitory effects of MyBP-C on contractility have been reported. To clarify the function of the regulatory N-terminal domains of MyBP-C, we det...

Some approaches to the assessment of moral intuitions are discussed. The controlled ethical trial isolates a moral issue from confounding factors and thereby clarifies what a person’s intuition actually is. Casuistic reasoning from situations, where intuitions are clear, suggests or modifies principles, which can then help to make decisions in situations where intuitions are unclear. When intui...

BACKGROUND Mild hypertrophy but increased arrhythmic risk characterizes the stereotypic phenotype proposed for hypertrophic cardiomyopathy (HCM) caused by thin-filament mutations. However, whether such clinical profile is different from more prevalent thick-filament-associated disease is unresolved. OBJECTIVES This study aimed to assess clinical features and outcomes in a large cohort of pati...

The contractile properties of the heart are the result of the interaction of a complex system of intracellular filaments (Gergely, 1966). These lie longitudinally in the cell and consist of alternating arrays of thick and thin filaments. The thin filaments arise from each side of transversely oriented Z lines and interdigitate with the thick filaments forming a structure which repeats along the...

OBJECTIVES To evaluate a possible relationship between gingival biotypes and gingival thickness, papilla height and gingival width. MATERIAL AND METHODS Thirty-six adult subjects were stratified by their gingival biotype (GB), as defined by transparency of a periodontal probe through the buccal gingival margin, into "thin" (18 subjects) and "thick" (18 subjects) GB. Out of these, extreme case...

Abstract All of us have personal ideals. We are committed to being good (enough) friends, parents, neighbors, teachers, citizens, human beings, and more. In this paper, I examine the thick thin aspects these ideals: (i) their substance (to internalize an ideal is endorse a particular way being) (ii) accountability reason assume that really be). considering how two interact in rational agency, a...

Some approaches to the assessment of moral intuitions are discussed. The controlled ethical trial isolates a moral issue from confounding factors and thereby clarifies what a person's intuition actually is. Casuistic reasoning from situations, where intuitions are clear, suggests or modifies principles, which can then help to make decisions in situations where intuitions are unclear. When intui...

a general theoretical description of dual-beam photothermallensing spectroscopy is given. the results are valid for most general conditions, that is, for flowing as well as stationary media, for optically thick as well as optically thin media, and also for any transverse modes of incident pump beams

In this paper we present a new chemical evolution model for the Galaxy which assumes two main infall episodes for the formation of halo-thick disk and thin disk, respectively. We do not try to take into account explicitly the evolution of the halo since our model is better suited for computing the evolution of the disk (thick plus thin) but we implicitly assume that the timescale for the format...