For the discovery of new antimicrobial drugs, derivatives sulfonamide having thiazole ring were synthesized. The series synthesized starting from 4-(arylsulfonamido)-acetophenone thiosemicarbazones 2a–f. Cyclization thiosemicarbazone 2a–f by using ethyl chloroacetate and chloroacetone gave thiazolidin-4-ones 3a–f 4-methylthiazoles 4a–e, respectively. properties compounds investigated. major no ...

The titled compounds were prepared by interaction of ethyl 2-(benzo[d]thazol-2-yl)acetate (3) with different arylidinemalononitrile derivatives (4a-c) in EtOH/TEA solution at room temperature. When 3 was treated with 2(ethoxymethylene)-malononitrile (4f) under same reaction conditions, the ethyl iminothiazolopyridine-4-carboxylate (6) was obtained. Ethyl (amino(methoxy)methyl)-3-(substitutedphe...

The aims of this study were to synthesize a series of thiosemicarbazones and their thiazole derivatives, to investigate their cytotoxic activity against three human cancers and normal (Vero cells) cell lines, and to evaluate the pro-apoptotic potential of the most active compounds. Materials and Methods: The thiosemicarbazones were obtained by reacting an aromatic aldehyde with thiosemicarbazid...

To develop effective insecticides against Lepidoptera pests, 25 novel N-pyridylpyrazole derivatives containing thiazole moiety were designed and synthesized based on the intermediate derivatization method (IDM). The insecticidal activities of these target compounds Plutella xylostella (P. xylostella), Spodoptera exigua (S. exigua), frugiperda frugiperda) evaluated. Bioassays indicated that comp...