kao “lijekova” nesvrhovita, i sada se joπ smatra racionalnim. Takav se stav o vitaminima polako ali sigurno mijenja. Tako je malo poznato da se rijedak oblik megaloblastiËne anemije praÊene dijabetesom melitusom i gluhoÊom moæe lijeËiti visokim dozama tiamina (engl. thiamine-responsive megaloblastic anemia; TRMA) (3). Ovaj je tip anemije autosomska recesivna bolest, u kojoj se prema najnovijim ...

Thiamine (vitamin B1) is required in the diet of animals, and thiamine deficiency leads to diseases such as beri-beri and the Wernicke-Korsakoff syndrome. Dietary thiamine (vitamin B1) consists mainly of thiamine pyrophosphate (TPP), which is transformed into thiamine by gastrointestinal phosphatases before absorption. It is believed that TPP itself cannot be transported across plasma membranes...

The present study was prompted by the observation that ingestion of large amounts of nicotinic acid resulted in a relatively large increase in the apparent excretion of thiamine by human subjects maintained on a constant low intake of thiamine. Although the daily excretion of thiamine had been at a fairly constant level, between 20 and 30 y for several months, after administration of 300 mg. of...

OBJECTIVE Thiamine is an essential component of cellular metabolism, and lack of this vitamin results in a potentially life-threatening biochemical lesion. The stress of surgery and critical disease depletes electrolytes, minerals, and essential biochemical substrates. We hypothesized that critical illness (represented by major surgery) would result in decreased thiamine levels over time. MET...

Thiamine, riboflavin and niacin are essential nutrients play vital role in oxidation-reduction reaction during energy production the living cell of body. Requirement these vitamins must be met through diet as human body cannot synthesize thiamine riboflavin. Small amount is synthesized but major requirement external diet. Jute leaves rich different minerals. Different varieties fresh jute well ...

AIMS To identify the early clinical indications of thiamine deficiency and to understand the factors involved in the development of the amnesic state in alcohol-dependent individuals with thiamine deficiency. It is hoped that this will highlight the need for clinicians to treat alcohol-dependent patients prophylactically with parenteral thiamine and thus prevent the development of Korsakoff's P...

OBJECTIVES to compare erythrocyte thiamine pyrophosphate concentrations in elderly people with those in healthy younger people; to determine if any differences can be attributed to age or to co-morbidities. DESIGN cross-sectional and 3-year longitudinal surveys. SETTING primary care. PATIENTS 100 volunteer blood donors and 222 elderly people from a general practice register. MEASUREMENT...

Thiamine (vitamin B1) is an essential enzyme cofactor in most organisms required at several stages of anabolic and catabolic intermediary metabolism. However, little is known on the positive effects of thiamine in diabetic type 1 (DMT1) patients. The objectives of this study were to evaluate the biochemical changes related to thiamine deficiency in patients with DMT1 outcomes among Saudi adults...

Polioencephalomalacia (PEM), also known as cerebrocortical necrosis, is an important neurologic disease that affects ruminants. Thiamine deficiency and sulfur (S) toxicity have been well recognized as major etiological factors. The mechanism of thiamine deficiency associated PEM has been well elucidated. However, the role of S in PEM pathogenesis remains unclear, although the relationship betwe...

BACKGROUND Oxidative liver injury occurring with methotrexate restricts its use in the desired dose. Therefore, whether or not thiamine and thiamine pyrophosphate, whose antioxidant activity is known, have protective effects on oxidative liver injury generated with methotrexate was comparatively researched in rats using biochemical and histopathological approaches. MATERIAL/METHODS Thiamine p...