medication errors (mes) are the most common error in icus. in fact, 78% of all serious errors in icus are due to mes. therefore, detecting mes has vital significance. the goal of this study was to investigate the frequency, type and consequences of different types of errors including prescribing, transcribing and administration errors in an icu of a large teaching hospital. disguised direct obs...

Therapeutic drug monitoring (TDM) of certain drugs with a narrow therapeutic index significantly improves patient outcome. For example, the quantification of immunosuppressive drugs in samples from patients after organ transplantation is an essential prerequisite for the prevention of both adverse drug reactions and rejection events. The need for accurate, precise, and standardized measurement ...

OBJECTIVES This article will review current data on the metabolism, interactions, methods of analysis, and adverse effects observed with the use of new anticonvulsant drugs. The role of the laboratory in the provision of therapeutic drug monitoring for these drugs is discussed. CONCLUSION Certain of the newer anticonvulsant drugs require therapeutic drug monitoring for their optimal use in th...

voriconazole is an antifungal triazole, approved for management of invasive fungal diseases in patients. it is absorbed during two hours and its serum levels will be above 90%, based on the underlying factors, when the drug is administered orally. voriconazole shows a propotional increase in an area under the plasma concentration-time curve (auc), with increasing dose. plasma protein binding of...