abstract the objective of present study was to evaluate pharmacokinetic parameters of dibudipine phytosolve after oral administration in rats. the solubility test was carried out to select suitable oily solvent for dibudipine. phytosolve formulation was prepared with a medium chain triglyceride (mct) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). the effect of polyol c...

We present a theoretical study on the idea of using mathematical programming relaxations for filtering binary constraint satisfaction problems. We introduce the consistent value polytope and give a linear programming description that is provably tighter than a recently studied formulation. We then provide an experimental study that shows that, despite the theoretical progress, in practice filte...

The effect of replacing hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by octahydro-1,3,5,7-tetranitro-1,3,5,7tetrazocine (HMX) in HTPB-binder on the performance, sensitivity, thermal, and mechanical properties of the sheet explosive formulation has been studied. The maximum loading of HMX was achieved up to 78 per cent in HTPB-binder system. The velocity of detonation (VOD) of HMX-based sheet e...

An important property for finite difference schemes designed on curvilinear meshes is the exact preservation of free-stream solutions. This property is difficult to fulfill for high order conservative essentially non-oscillatory (WENO) finite difference schemes. In this paper we explore an alternative flux formulation for such finite difference schemes [5] which can preserve free-stream solutio...

This paper presents a nite element formulation for solving multidimensional compressible ows. This method is inspired by our experience with the SUPG, Finite Volume and Discontinuous-Galerkin methods. Our objective is to obtain a stable and accurate nite element formulation for multidimensional hyperbolic-parabolic problems with particular emphasis on compressible ows. In the proposed formulati...

The study involves theoretical formulation, model development and verification, and integration with field observations of swash motions. The starting point of the theoretical formulation is the Euler equation of motion for waves and currents above the permeable seabed and the locally-averaged Navier-Stokes equations for the flow inside the porous layer. A complete set of fully nonlinear Boussi...

Several real-world systems, such as gene expression networks in biological cells, contain coupled chemical reactions with a time delay between reaction initiation and completion. The non-Markovian kinetics of such reaction networks can be exactly simulated using the delay stochastic simulation algorithm (dSSA). The computational cost of dSSA scales with the total number of reactions in the netw...

When a mountaineer is ascending one of the great peaks of the Himalayas she knows that an entirely new vista awaits her at the top, whose ramifications will be known only after she gets there. Her immediate goal though, is to tackle the obstacles on the way up, and reach the peak. In a similar vein, one of the immediate goals of contemporary theoretical physics is to build a quantum, unified de...

This study explores the relationship between undergraduates’ epistemological beliefs and their information-seeking behavior. Kuhlthau’s information search process (ISP) model and four models of epistemological development from educational psychology formed the theoretical foundation of this investigation. Twenty undergraduates attending an Ivy League university were interviewed about their sear...

omega-3 fatty acids (fas) have been shown to prevent cardiovascular disease. the most commonly used omega-3 fatty acids like eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) are highly vulnerable to oxidation and therefore, have short shelf life. recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 fas. several methods could be implemented to prepar...