Gene targeting studies have shown that the transcription factor SCL is critically important for embryonic hematopoiesis, but the early lethality of SCL null mice has precluded the genetic analysis of its function in the adult. We have now generated a conditional knockout of SCL by using CreLox technology and an IFN-inducible Cre transgenic mouse. Deletion of SCL in adult mice perturbed megakary...

Background: Cognitive theories of attention-deficit/hyperactivity disorder (ADHD) propose that high within-subject fluctuations of cognitive performance in ADHD, particularly reaction time (RT) variability (RTV), may reflect arousal dysregulation. Yet, direct evidence of arousal dysregulation and how it may account for fluctuating reaction times in ADHD is limited. We used skin conductance (SC)...

The SCL gene encodes a basic helix-loop-helix transcription factor which is expressed in early haematopoietic progenitors throughout ontogeny and is essential for the normal development of blood and blood vessels. Transgenic studies have characterised spatially distinct 5' enhancers which direct lacZ expression to subdomains of the normal SCL expression pattern, but the same elements failed to ...

Purpose To explore the mechanism that shapes firms' supply chain learning (SCL) practices, this study examines relationship between knowledge network embeddedness and their SCL practice in a network, as well moderating role of cohesion relationship. Design/methodology/approach Using patent application data partner information from 869 listed firms 2011 2020 China, uses fixed-effect regression m...

INTRODUCTION Fracture healing is a complex biological process involving inflammation, granulation, callus formation, and bone modeling/remodeling. Optimal fracture healing results in complete restoration of bone structure and function to the pre-fracture levels. However, some fractures are associated with a high risk of delayed union, non-union and other complications. This leads to significant...

This study describes and presents the analysis for the Source-Coupled Logic (SCL) inverter as will as the effect of submicron layout parasitics. The SCL inverter circuit model and its operation is defined. The analysis for the SCL is carried from the point of view of input/output voltage characteristics and the effect of noise margin. The inverter gate delay model is described and the effect of...

The product of the SCL gene is a basic helix-loop-helix (bHLH) transcription factor that is essential for the development of hematopoietic stem cells in both the embryo and the adult. However, once the stem cell compartment is established, the function of SCL in subsequent differentiation and commitment events within normal hematopoietic cells remains undefined. The aim of the current study was...

The stem cell leukemia gene SCL, also known as TAL-1, encodes a basic helix-loop-helix transcription factor expressed in erythroid, myeloid, megakaryocytic, and hematopoietic stem cells. To be able to make use of the unique tissue-restricted and spatio-temporal expression pattern of the SCL gene, we have generated a knock-in mouse line containing the tTA-2S tetracycline transactivator under the...

In Caenorhabditis elegans, an insulin-like signaling pathway, which includes the daf-2 and age-1 genes, controls longevity and stress resistance. Downregulation of this pathway activates the forkhead transcription factor DAF-16, whose transcriptional targets are suggested to play an essential role in controlling the phenotypes governed by this pathway. We have surveyed the genes that have the D...

The Symptom Checklist 90 Revised (SCL-90-R) is a widely used assessment of mental health pathology. Its factor structure has been called into question by numerous studies. This study assessed a community mental health outpatient sample (n = 336) with the SCL-90-R and analyzed the factor structure. The results indicated that the SCL-90-R measures one large factor, but the test items held togethe...