An ethnically Chinese patient with newly diagnosed metastatic gastro-intestinal stromal tumour initially treated with imatinib mesylate developed severe interstitial lung disease. As his condition improved after cessation of imatinib mesylate and treatment with corticosteroids, he was started on sunitinib malate. His clinical course was then unfortunately complicated with intra-tumour bleeding....

Meckel's diverticulum is the most common congenital anomaly of the gastro-intestinal tract. It arises as a result of incomplete dissolution of the vitello-intestinal duct. Approximately 4% of patients with Meckel's diverticula develop complications, most commonly obstruction, gastro-intestinal bleeding and inflammation. We describe three unusual presentations of Meckel's diverticulum-perforatio...

OF the various gastric fistulae described in the literature those communicating with the bronchi appear to be among the rarest. Aird (1957) devotes only four lines to the subject while Milne and Thompson (1970) state that a careful search of medical literature failed to reveal any reference to the condition. This is somewhat misleading as the literature since 1960 contains seven case reports an...

Primary aorto-duodenal fistula is a rare and life-threatening cause of upper gastro-intestinal bleed. In this case report, a patient presented acutely with several episodes of haematochezia and pulseless lower limbs bilaterally. Primary aorto-duodenal fistula with peripheral vascular disease was diagnosed after an urgent CT angiogram was performed. She underwent left axillo-bifemoral bypass, re...

A 26-year-old woman was regularly followed up in a gastro-intestinal out-patient clinic. Since early childhood, she was noted to have hyperpigmented lesions over the perioral region (Fig 1a) and fingers (Fig 1b), and a history of small intestinal intussusception due to polyps that was treated by surgery when she was 12 years old. Endoscopic assessment revealed multiple gastric polyps (Fig 1c) a...

To date, most concepts on the frequency of gastro-oesophageal reflux episodes and the efficiency of the antireflux barrier have been based on inferences derived from measurement of oesophageal pH. The development of intraluminal impedance monitoring has highlighted the fact that pH monitoring does not detect all gastro-oesophageal reflux events when little or no acid is present in the refluxate...

In adults, most intussusceptions develop from a lesion, usually a benign or malignant neoplasm, and can occur at any site in the gastrointestinal tract. Intussusception in the proximal gastrointestinal tract is uncommon, and gastro-gastric intussusception is extremely rare. We present a case of gastro-gastric intussusception secondary to a primary gastric lymphoma. An 82-year-old female patient...

Gastro-esophageal reflux (GER) is common in infants and children and has a varied clinical presentation: from infants with innocent regurgitation to infants and children with severe esophageal and extra-esophageal complications that define pathological gastro-esophageal reflux disease (GERD). Although the pathophysiology is similar to that of adults, symptoms of GERD in infants and children are...

An ectopic pancreas is defined as pancreatic tissue outside its normal location, anatomically separated from the pancreas.The transcription factor pancreas/duodenum homeobox protein 1 (PDX1) involved in maintaining and functions early development, beta cell differentiation, endocrine non cells. Pancreatic subunit alpha (PTF1A) affects exocrine formation regulation of acinar identity, expressed ...

Gastro-oesophageal reflux disease (GERD) is associated with substantial morbidity in patients systemic sclerosis. Although the introduction of proton pump inhibitors (PPIs) into clinical care represents a major achievement management gastro-oesophageal problems sclerosis, PPIs are seldom fully effective and use maximum PPI doses very frequent practice. However, there little evidence to support ...