Extracellular superoxide dismutase (EC-SOD), which scavenges extracellular superoxide (O.), is highly regulated in the developing lung. In the prenatal rabbit, EC-SOD is predominantly intracellular and inactive, and postnatally, active EC-SOD is secreted. We hypothesized that prenatal hypoxia would delay the normal postnatal secretion of active EC-SOD in the lung. Pregnant New Zealand White rab...

Earlier studies on human sperm cryodamage have shown that plasma membrane stress is the primary process and that phospholipid peroxidation in cryopreserved samples is not inhibited by addition of antioxidants. One consistent effect of cryopreservation is loss of enzymatic activity of the peroxidation defense enzyme, superoxide dismutase (SOD). To clarify this aspect of the freeze-thaw process a...

Superoxide dismutase (SOD) is a crucial metal-containing enzyme that plays vital role in catalyzing the dismutation of superoxide anions, converting them into molecular oxygen and hydrogen peroxide, essential for enhancing plant stress tolerance. We identified 8 SOD genes (4 CSODs, 2 FSODs, MSODs) cassava. Bioinformatics analyses provided insights chromosomal location, phylogenetic relationship...

Cu2Zn2-superoxide dismutase (CuZn-SOD) was purified from chicken liver. The liver enzyme had a subunit Mr of 16900 and contained equimolar amounts of copper and zinc [0.260 (w/w) for each]. Aortic CuZnSOD had the same Mr as estimated by gel filtration and cross-reacted with antibodies to the liver enzyme. Both enzymes were inhibited by 1.0 mM-NaCN. Within 24-72 h after hatching, total SOD activ...

The antioxidant activity of the melia azedarach was investigated in rats with ethanol-induced erythrocyte damage. Chronic administration of ethanol (20% w/v, 2 g/kg.p.o.,daily for four weeks) increased the level of lipid peroxidation (LPO), decreased the activity of superoxide dismutase (SOD) and catalase and reduced the content of glutathione (GSH). The concurrent treatment of ethanol-admini...

objective: elevated amino acid homocysteine (hcy) levels and insufficient physical activity are the risk factors in alzheimer disease (ad) development. the effect of intermittent aerobic training on memory retention test and thiobarbituric acid reactive substances (tbars) and superoxide dismutase (sod) levels in the dorsal hippocampus of rats which were stimulated with hcy is investigated. meth...

Although production of reactive oxygen species (ROS) such as superoxide (O(2)(.-)) has been implicated in chronic hypoxia-induced pulmonary hypertension (PH) and pulmonary vascular remodeling, the transcription factors and gene targets through which ROS exert their effects have not been completely identified. We used mice overexpressing the extracellular antioxidant enzyme extracellular superox...

supplementation has beneficial effects in immune system and can antioxidant enzymes activity increases during the exercise and protects the tissue against the oxidative stress. l-carnitine is a famous supplement and helps to protect against the oxidative stress during and after intense or prolonged exercise. the aim of this study was to investigate the effect of l-carnitine supplementation on t...