Some routine red blood cell (RBC) measurements and indexes (count, mean volume, volume dispersion, and mean hemoglobin [HGB] concentration) can be used to differentiate iron deficiency from heterozygous beta-thalassemia. A number of formulas that incorporate two or more of these measurements have been described to amplify such differences. The H*1 hematology analyzer directly measures volume an...

Introduction: Hemoglobinopathies and thalassemias are the most common single gene disorders in world. World Health Organization figures estimate that 5% of world populations carriers a potentially pathological hemoglobin (Hb) gene. The general incidence thalassemia trait sickle cell anaemia India varies between 3-17% 1-44% respectively3 but because consanguinity, caste area endogamy, some commu...

We report the case of a 42 year male with history of chronic anaemia who was found to have pernicious anaemia with beta thalassemia trait and had on esophago-gastric-duodenoscopy, gastric carcinoids with gastric atrophy. Pernicious anaemia and gastric carcinoids occurring simultaneously in a single individual is rare. Our case emphasises the need for esophago-gastric-duodenoscopy in cases of pe...

BACKGROUND We aimed to determine the incidence of co-inheritance as well as interaction of sickle cell trait (SCT) and α(thal)/β(thal) mutations in south and south central of Iran. METHOD We employed a PCR and restriction fragment length polymorphism techniques to confirm diagnosis of sickle cell trait. All subjects were screened for any α/β -thalassemia mutations using a gap-polymerase chain...

BACKGROUND AND AIMS Thalassemia is curable by bone marrow transplantation; however, finding suitable donors with defined HLA combination remains a major challenge. Cord blood stem cells with preselected HLA system through preimplantation genetic diagnosis (PGD) proved very useful for resolving scarce HLA-matched bone marrow donors. METHODS A thalassemia trait couple with an affected child was...

Aim and Objective: To evaluate usefulness of Single Tube Osmotic Fragility Test (SOFT) for detection of microcytosis and its further application for thalassemia trait screening. Background: Iron deficiency and thalassemia are common causes of microcytic anaemia in Pakistan. Easy microcytosis screening is necessary at a low resourced country like Pakistan, so that further investigations speciall...

Five hundred apparently healthy adults from northern parts of Punjab and NWFP were screened for the prevalence of heterozygous beta-thalassemia. The trait was detected in all ethnic groups with an overall prevalence rate of 5.4% (27/500). Pathans had significantly (P less than 0.02) higher prevalence rate (7.96%) than Punjabis (3.26%).