Male-biased genes have drawn considerable attention due to their relatively rapid rates of interspecies diversification. These genes are often involved in processes related to reproductive behavior, sexual competition, and gametogenesis. Despite this trend toward rapid evolutionary change, many core molecular pathways underlying spermatogenesis are conserved between Drosophila melanogaster and ...

background use of medicinal plants with high antioxidant properties could be effective to increase fertility and improvement of disorders such as hormonal imbalance, impotency, oligospermia and immotile sperm. celery (apium graveolens) is rich in antioxidant agents. the leaf and stems of celery contain phenols, furanocoumarin and luteolin. apigenin is one of the main flavonoids of celery leaf. ...

Experimental hypothyroidism during sexual development Testes size and number of spermatozoa in adulthood are determined by postnatal/pubertal proliferation of seminal tubule somatic cell constituents, the Sertoli cells. Cessation of proliferation of Sertoli cells during early development occurs concomitantly with formation of their terminally differentiated population. Transient experimental hy...

We present a case of Kallmann syndrome in a 33-years-old man. He was unable to sense smell since birth. He showed scale-out results on T&T olfactogram. He displayed non-development of secondary sexual characteristics for the past 20 years. On urological examination, he had sparse pubic hair, right undescended testis, and small penis. Blood investigations showed low basal levels of serum testost...

3 year unmarried male presented with loss of appetite, malaise, left upper quadrant abdominal discomfort since 3 months. Patient was found to have massive splenomegaly. Patient also had gynecomastia, lack of facial hair and sparse axillary and pubic hair (Figure 1A, 1B). He gave history of absent puberty and lack of development of secondary sexual characters. On geni ta l examinat ion , pat ien...

Globally Harmonized System defines Reproductive Toxicity as “an adverse effects (of chemicals) on sexual function and fertility in adult males and females, as well as developmental toxicity in the offspring.” Several toxicity assessment studies have been performed taking into account the action of toxicants on reproductive activity. Testis is the main organ of male reproductive system and sperm...

ammalian sex-determining factors with homology to DNA binding proteins are required for splicing, according to a study by Paolo SassoneCorsi and coworkers at the Université Louis Pasteur (Strasbourg, France). Examination of high mobility group (HMG) domain containing SRY and Sox proteins demonstrated a surprising but clear association with splicing complexes. SRY, the testis-determining factor ...

In mammals, Sry (sex-determining region Y gene) is the master regulator of male sex determination. The discovery of Sry in 1990 was expected to provide the key to unravelling the network of gene regulation underlying testis development. Intriguingly, no target gene of SRY protein has yet been discovered, and the mechanisms by which it mediates its developmental functions are still elusive. What...

ammalian sex-determining factors with homology to DNA binding proteins are required for splicing, according to a study by Paolo SassoneCorsi and coworkers at the Université Louis Pasteur (Strasbourg, France). Examination of high mobility group (HMG) domain containing SRY and Sox proteins demonstrated a surprising but clear association with splicing complexes. SRY, the testis-determining factor ...

The Leydigioma is a rare tumor of the testicle. It develops from the proliferation of the interstitial cells or Leydig cells, and compete with the endocrine activity of this organ.[1] It usually arises between 20 year and 50 year of life, and rarely reported in children.[2] International literature is rich about the management of testicular tumors in adults and often recommends radical orchidec...