Several reports supported that continuous exposure to 60 Hz magnetic field (MF) induces testicular germ cell apoptosis in vivo. We recently evaluated durationand dose-dependent effects of continuous exposure to a 60 Hz MF on the testes in mice. BALB/c male mice were exposed to a 60 Hz MF at 100 μT for 24 hours a day for 2, 4, 6, or 8 weeks, and at 2, 20 or 200 μT for 24 hours a day for 8 weeks....

The capacity of testicular somatic cells to promote and sustain germ cell differentiation is largely regulated by sexual steroids and notably androgens. In fish species the importance of androgens is emphasized by their ability to induce sex reversal of the developing fries and to trigger spermatogenesis. Here we studied the influence of androgens on testicular gene expression in trout testis u...

Ovaries are paired pelvic organs located on thesides of the uterus. Although it is rare in general population, between age group 20-40 years males,Testicular germ cell neoplasms most common form malignant tumour reported. In young women ovarian tumours rank second among tumors and males, testicular tumorsserves as leading percentage all seen early late adulthood (3rd 4th decade) life. The peopl...

Background: Germ cell aplasia is a type of azoospermia characterized by hormonal abnormalities as well as histopathological features. Objective: To assess hormonal and histological aspects of germ cell aplasia among infertile men in Gaza Strip. Materials and methods: A total of 375 infertile men visiting the Specialized Medical Centers in Gaza strip were subjected for testicular biopsy. Out of ...

Testicular granulosa cell tumors are extremely rare in adults. We report a case of a testicular germ cell tumor (GCT) in a 21-year-old man. The tumor was treated successfully with radical orchiectomy, and follow-up computed tomography revealed no evidence of recurrence or metastasis 10 months postoperatively. The clinical and histopathological features, treatment, and prognosis of testicular GC...

The prevalence of testicular germ cell tumors (TGCT), a common solid tissue malignancy in young men, has been annually increasing at an alarming rate of 3%. Since the majority of testicular cancers are derived from germ cells at the stage of transformation of primordial germ cell (PGC) into gonocytes, the increase has been attributed to maternal/fetal exposures to environmental factors. We exam...

Extragonadal germ cell tumors are extremely rare and account for only 3%-5% of all germ cell tumors. These tumors are rarely associated with metachronous primary testicular germ cell tumors. We report the fourth case of a primary germ cell tumor occurring after the treatment of a primary CNS germ cell tumor in a 27 year-old male with embryonal cell carcinoma of the testicle 9 years after the tr...

This study investigates the role of neutrophils in ischemia-induced aspermatogenesis in the mouse. Previous studies in the rat have demonstrated that ischemia-inducing testicular torsion followed by torsion repair and reperfusion resulted in germ cell-specific apoptosis. This was correlated with an increase in neutrophil adhesion to subtunical venules, an increase in reactive oxygen species, an...

This study investigates the possible involvement of nitric oxide synthase (NOS) in activating germ cell death in monkeys after mild testicular hyperthermia and/or hormonal deprivation. Groups of 8 adult male monkeys received 1 of the following treatments for 12 weeks: 1) 2 empty Silastic implants, 2) 2 testosterone (T) implants, 3) daily exposure of testes to heat (43 degrees C for 30 minutes) ...