STUDY HYPOTHESIS Is it possible to immunologically activate human cervical epithelial cells to produce antiviral factors that inhibit herpes simplex virus type 2 (HSV-2) replication? STUDY FINDING Our results indicate that human cervical epithelial cells possess a functional TLR3/RIG-I signaling system, the activation of which can mount an Interferon-λ (IFN-λ)-mediated anti-HSV-2 response. ...

Abstract A numerical investigation for simulating the aircraft cabin as an environmental chamber is set to assist a test rig design assimilating passenger comfort, considering their exposure high concentrations of Volatile Organic Compounds. Computational Fluid Dynamics used evaluate flow inside 800 sec actual time, where mixing and transport chemical species are also evaluated. Measurements cl...

BACKGROUND Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig-I had broader roles in antibacterial immunity and cancer protection. However, the potential roles and mechanisms of Rig-I in gut flora regulation and colorectal cancer (CRC) pr...

The ‘Binaural Transfer Path Analysis and Synthesis (BTPA and BTPS)’ techniques have been developed for the prediction of sound quality in vehicles not only in terms of numbers and graphs, but also for binaural auralisation. The methodology, based on a combination of test rig measurements and acoustic simulation, has been used successfully by HEAD acoustics in the last several years within numer...

This paper presents two nonlinear model-based control designs for a hydraulic system that consists of two mechanically coupled hydraulic cylinders actuated each by a separate servo-valve. Based on a physically-oriented nonlinear mathematical model of the test rig, a further model simplification results in a completely controllable MIMO system. Two different control structures are discussed and ...

AbstructThe p synthesis design method was evaluated for a flexible rotor magnetic bearing system with a five-axis-control system using both simulations and experiments. After modeling the full-order system using the finite element method, we obtained a reduced-order model in the modal domain by truncating the flexible modes. After choosing appropriate weighting functions with respect to frequen...

It is suggested that unicompartmental knee replacement (UKR) offers the potential to restore normal knee kinematics better than total knee replacement (TKR) because of retaining the cruciate ligaments, and better preservation of the overall geometry. It was hypothesized that patient-specific UKR would restore normal knee kinematics even better because of a customised articular shape. A comparat...