Deficient production of anti-viral interferons (IFNs) may be involved in causing viral-induced asthma exacerbations. Hence, drugs inducing lung IFN production would be warranted. Azithromycin may reduce asthma exacerbations but its modus operandi is unknown. Here, we investigated if azithromycin induces IFNβ expression in vitro in rhinovirus-infected bronchial epithelial cells from asthmatic do...

PURPOSE OF REVIEW Although the recommended treatment for syphilis is penicillin, azithromycin has been used as an alternative. We discuss azithromycin-related treatment failures and resistance in Treponema pallidum, and propose ways to meet the resulting clinical and public health challenges. RECENT FINDINGS Azithromycin treatment failures in syphilis were first noted in San Francisco in 2002...

BACKGROUND Single-dose azithromycin is recommended over multi-dose doxycycline as treatment for chlamydial infection. However, even with imperfect adherence, doxycycline is more effective in treating genital and rectal infection. Recently, it has been suggested that autoinoculation from the rectum to the genitals may be a source of persistent chlamydial infection in women. We estimated the impa...

Oral Azithromycin for the Treatment ofMeibomitis Commontreatment regimens formeibomitis includeeyelidhygiene, lubricants, topical antibiotics, topical steroids, and systemicmedications.1Azithromycin isamacrolideantibioticwith robust antimicrobial and anti-inflammatory properties,2 and topical azithromycin, 1%, ophthalmic solution (AzaSite) has been shown to be efficacious in treating anterior a...

In a recent issue of Clinical Ophthalmology, Friedlaender and Protzko (2007) review the development and effi cacy of 1% azithromycin in DuraSite ® (AzaSite™, Inspire Pharmaceuticals , Inc., Durham, NC) for the treatment of bacterial conjunctivitis. The authors conclude that 1% azithromycin in DuraSite offers a simplifi ed dosing regimen with sustained bactericidal levels that decrease resistanc...

The purpose of this study was to compare the concentrations of levofloxacin and azithromycin in steady-state plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) after intravenous administration. Thirty-six healthy, nonsmoking adult subjects were randomized to either intravenous levofloxacin (500 or 750 mg) or azithromycin (500 mg) once daily for five doses. Venipuncture and bron...

A total of 389 children (age 0.6-10.2 years) with typical signs and symptoms of acute otitis media were randomized (1:1) to treatment with either azithromycin or co-amoxiclav. The dosage schedule for azithromycin was 10 mg/kg/day, in a single daily dose, administered for three days. Co-amoxiclav was given at a dose of 13.3 mg/kg (amoxycillin equivalent) tid for ten days. Patients were evaluated...

BACKGROUND Exacerbations of asthma cause a substantial global illness burden. Adults with uncontrolled persistent asthma despite maintenance treatment require additional therapy. Since macrolide antibiotics can be used to treat persistent asthma, we aimed to assess the efficacy and safety of oral azithromycin as add-on therapy in patients with uncontrolled persistent asthma on medium-to-high do...

In a recent issue of Clinical Ophthalmology, Friedlaender and Protzko (2007) review the development and effi cacy of 1% azithromycin in DuraSite ® (AzaSite™, Inspire Pharmaceuticals , Inc., Durham, NC) for the treatment of bacterial conjunctivitis. The authors conclude that 1% azithromycin in DuraSite offers a simplifi ed dosing regimen with sustained bactericidal levels that decrease resistanc...

BACKGROUND Recent WHO guidelines recommend dual therapy with ceftriaxone or cefixime plus azithromycin for gonorrhea. Azithromycin in combination with gentamicin or spectinomycin has been recommended in treatment failure cases. Due to emergence of multi-drug resistant (MDR) and extensively-drug resistant (XDR) Neisseria gonorrhoeae strains, it is important to look for efficacy of these combinat...