AMILORIDE-SENSITIVE ACTIVE TRANSPORT of Na across the alveolar epithelium removes lung liquid in the neonate and protects against edema in the adult. Several lines of evidence have established that this process is stimulated by b-adrenergic agents via elevation of cAMP. First, when the lungs are filled with saline in vivo, then b-adrenergic agents or exogenous cAMP stimulates removal of this li...

AMILORIDE-SENSITIVE ACTIVE TRANSPORT of Na across the alveolar epithelium removes lung liquid in the neonate and protects against edema in the adult. Several lines of evidence have established that this process is stimulated by b-adrenergic agents via elevation of cAMP. First, when the lungs are filled with saline in vivo, then b-adrenergic agents or exogenous cAMP stimulates removal of this li...

AMILORIDE-SENSITIVE ACTIVE TRANSPORT of Na across the alveolar epithelium removes lung liquid in the neonate and protects against edema in the adult. Several lines of evidence have established that this process is stimulated by b-adrenergic agents via elevation of cAMP. First, when the lungs are filled with saline in vivo, then b-adrenergic agents or exogenous cAMP stimulates removal of this li...

An investigation was carried out to determine whether the sensitivity of rat tracheal smooth muscle to contractile and relaxant drugs was affected by three weeks' treatment with subcutaneous budesonide before death. Budesonide treatment was associated with a lower thymus weight and a smaller gain in body weight than in control animals. There was, however, no difference in the carbachol concentr...

A stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been developed for the determination of terbutaline sulfate (TBS) as a bulk drug and in pharmaceutical formulations (submicronized dry powder inhalers). The separation was achieved on TLC aluminum plates precoated with silica gel 60F-254 using chloroform-methanol (9.0:1.0 v/v) as mobile phase. The densitometri...

This case report describes events that occurred under general anaesthesia of a dog undergoing transvenous pacemaker implantation for third-degree atrioventricular block. Following premedication with acepromazine and buprenorphine, was induced alfaxalone, maintained isoflurane in oxygen. The developed severe hypotension during the procedure concurrent bradycardia before commencement pacing. In o...

Studies performed in adults with long-standing obesity suggest a reduced lipolytic sensitivity to catecholamines in subcutaneous abdominal adipose tissue (AT). We used microdialysis to study the in situ lipolytic effects of dobutamine (selective beta1-agonist) and terbutaline (selective beta2-agonist) on glycerol release (lipolytic index) in abdominal subcutaneous AT in 10 obese girls aged 13-1...

The adrenergic receptors in the isolated feline middle cerebral artery were characterized pharmacologically using a sensitive system for recording circular contractions in vitro. Epinephrine, norepinephrine, isoproterenol. and phenylephrine contracted the vessel in the mentioned order of potency. Together with the inhibitory patterns obtained with graded doses of piperoxan (reversible competiti...

A questionnaire was sent to physicians with an interest in chest disease to determine the dose and method of delivery of nebulised beta agonists in hospital. All of the 67 physicians replying gave beta agonists by nebuliser, and all reported either salbutamol (72%) or terbutaline (10%) as the drug they prescribed most commonly (18% gave either drug). There was a fivefold difference in the dose ...