Nuclear transcription factor B (NF-B) regulates innate and adaptive immunity functions mediates inflammatory responses by activating proinflammatory cytokine gene transcription. TNF inhibitors block the NF-B signaling pathway, thus reducing activity. The aim of study was to evaluate informativity NF-kB determination in lymphocyte populations children with bowel disease (IBD) psoriasis assess ef...

Discovery of the IL-23/Th17 axis brought to an end the era of the Th1/Th2 paradigm and radically advanced our understanding of autoimmunity. Experimental autoimmune encephalitis (EAE), an animal model of multiple sclerosis (MS), was highly instrumental in discovery of the IL-23/Th17 axis and the ensuing rapid progress in the field. Despite an early start and subsequent intense focus on the role...

Nocardia brasiliensis is an intracellular microorganism and the most common etiologic agent of actinomycetoma in the Americas. Several intracellular pathogens induce an immunosuppressive microenvironment through increases in CD4+ Foxp3+ regulatory T cells (Treg), thus downregulating other T-cell subpopulations and assuring survival in the host. In this study, we determined whether N. brasiliens...

T-cells undergo polyclonal expansion in cutaneous psoriasis (PsC) and PsA, with persistence of “driver clones” after effective treatment (JCI 127:4031; JI 172:1935). A recent scRNA-seq study found roughly equal compartments clonal non-clonal Th17 Tc17 cells PsC (Science 371:364). We others have shown that from PBMC requires contact between monocytes memory the context TCR ligation (PNAS 104:170...

The presence and clinical significance of interleukin (IL)-17 and IL-17-expressing cells have recently been studied in several types of cancer, but their correlation to tumor development remains controversial. Additionally, the contribution of peripheral IL-17-expressing cells to head and neck cancer (HNC) progression is still poorly understood. We collected peripheral blood from healthy donors...

Comprehensive studies of the frequencies and absolute numbers of the various cell lineages that synthesize IL-17 in the blood and corresponding gastrointestinal (GI) tissues, their correlation with CD4(+) Tregs, CD8(+) Tregs, total and IFN-α synthesizing plasmacytoid dendritic cells (pDC) relative to plasma viral load in SIV infection has been lacking. The unique availability of SIV infected rh...