En este trabajo, aprovechando las ventajas del uso de derivadas orden fraccionario en el sentido Caputo, presentamos un estudio control óptimo la eficacia tratamiento tuberculosis (TB) presencia VIH/SIDA y diabetes. El modelo matemático que es controlado se encuentra [17] estudia relación entre tuberculosis, diabetes con respecto a diferencia multirresistente (TB-MDR), extremadamente resistente...

background: tuberculosis (tb) is a pandemic disease. it is the second leading cause of death from infectious diseases after human immunodeficiency virus (hiv) in the world . the main objective of this paper was to determine and compare the epidemiology of tb incidence rate and its trend changes during 1990-2010 in six who regions regarding age, gender and income levels. methods: the average ann...

background tuberculosis (tb) continues to be a major public health problem worldwide. in developing countries, the burden of the disease is explosive, as 95% of global tb patients reside and 98% of global tb deaths occur in these regions. patients’ satisfaction may play a major role in adherence to medications and hence improve tuberculosis cure rate. objectives the current study aimed firstly ...

Multidrug-resistant (MDR)- tuberculosis (TB) and extensively drug resistant (XDR)-TB reportedly lead to increased household transmission. This is a retrospective cohort study of active TB occurring among household contacts exposed to MDR-TB. Of 704 contacts in 246 households, initial screening identified 12 (1.7%) TB cases (prevalent cases) and 17 (2.4%) contacts that subsequently developed act...

BACKGROUND Quick diagnosis of smear-negative pulmonary tuberculosis (TB) and extra-pulmonary TB are urgently needed in clinical diagnosis. Our research aims to investigate the usefulness of the interferon-γ release assay (IGRA) for the diagnosis of smear-negative pulmonary and extra-pulmonary TB. METHODS We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients (including 120 sm...

background cavitary pulmonary tuberculosis (tb) is rare in children. objectives the aim of this study was to evaluate the characteristics of cavitary pulmonary tb in children. patients and methods this retrospective study was conducted on 97 children less than 15 years old with pulmonary tb to assess the clinical characteristics and radiographic findings of patients with cavitary lesions. resul...

Background The unregulated availability and irrational use of tuberculosis (TB) medicines is a major issue of public health concern globally. Governments of many low- and middle-income countries (LMICs) have committed to regulating the quality and availability of TB medicines, but with variable success. Regulation of TB medicines remains an intractable challenge in many settings, but the reason...

Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...

BACKGROUND Drug-resistant tuberculosis (TB) is a serious threat in industrialized countries, but information from Southern Italy is lacking. Here, we present the results of a retrospective study of TB cases diagnosed in 2008-2013 in Naples, the largest city in Southern Italy. METHODS Six hundred ninety Mycobacterium tuberculosis strains were isolated at the Ospedali dei Colli of Naples, and r...