نتایج جستجو برای: targeted gene delivery

تعداد نتایج: 1430970  

Journal: :Chemical Society Reviews 2019

Journal: :Angewandte Chemie International Edition 2014

Journal: :Molecular Therapy 2014

Journal: :Journal of Biomedicine and Biotechnology 2006

Journal: :ISRN Pharmacology 2012

Journal: :Materials Today 2005

Journal: :Materials Today 2013

2017
Nan Jiang Qian Chen Sheng Cao Bo Hu Yi-Jia Wang Qing Zhou Rui-Qiang Guo

The development of an efficient delivery system is critical for the successful treatment of cardiovascular diseases using non‑viral gene therapies. Cytoplasmic and nuclear membrane barriers reduce delivery efficiency by impeding the transfection of foreign genes. Thus, a gene delivery system capable of transporting exogenous genes may improve gene therapy. The present study used a novel strateg...

Journal: :Molecular pharmaceutics 2009
Xu-Li Wang Rongzuo Xu Xueming Wu David Gillespie Randy Jensen Zheng-Rong Lu

In this study, novel peptide-targeted delivery systems were developed for systemic and targeted delivery of therapeutic siRNA based on a multifunctional carrier, (1-aminoethyl)iminobis[N-(oleicylcysteinylhistinyl-1-aminoethyl)propionamide] (EHCO), which showed pH-sensitive amphiphilic cell membrane disruption. EHCO formed stable nanoparticles with siRNA. Targeted siRNA delivery systems were rea...

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