Salvage radiotherapy (SRT) represents the main treatment option for relapsing prostate cancer in patients after radical prostatectomy. Several open questions remain unanswered in terms of target volumes definition and delivered doses for SRT: the effective dose necessary to achieve biochemical control in the SRT setting may be different if the tumor recurrence is micro- or macroscopic. At the s...

Hypertensive urgencies are common clinical occurrences in hypertensive patients. The definition of hypertensive urgencies (target blood pression) were not consistent, but involved often target end-organ damage in emergencies. Epidemiology and physiopathology are briefly described. Treatment practices of hypertensive crisis were difficult because of the lack of evidence supporting the use of one...

........................................................................................................... x CHAPTER 1. GENERAL INTRODUCTION ........................................................ 1 BACKGROUND ................................................................................................ 1 METHODS FOR ASSEMBLING TALENs. ...................................................... ...

GT-2 is a nove1 DNA binding protein that interacts with a triplet of functionally defined, positively acting GT-box motifs (GT1-bx, GT2-bx, and GT3-bx) in the rice phytochrome A gene (PHYA) promoter. Data from a transient transfection assay used here show that recombinant GT-2 enhanced transcription from both homologous and heterologous GT-box-containing promoters, thereby indicating that this ...

LTR-containing retrotransposons reverse transcribe their RNA genomes, and the resulting cDNAs are integrated into the genome by the element-encoded integrase protein. The yeast LTR retrotransposon Ty1 preferentially integrates into a target window upstream of tDNAs (tRNA genes) in the yeast genome. We investigated the nature of these insertions and the target window on a genomic scale by analyz...

Current treatments of high-grade lymphoma often have curative potential, but unfortunately many patients relapse and develop therapeutic resistance. Thus, there remains a need for novel therapeutics that can target the residual cancer cells whose phenotypes are distinct from the bulk tumor and that are capable of reforming tumors from very few cells. Oncolytic viruses offer an approach to destr...

OBJECTIVE The objective of the study was to evaluate locoregional control after intensity-modulated radiotherapy for nasopharyngeal cancer using a target definition along with anatomical boundaries. METHODS Forty patients with biopsy-proven squamous cell or non-keratinizing carcinoma of the nasopharynx who underwent intensity-modulated radiotherapy between April 2006 and November 2009 were re...

I give an account of the definitions of parton densities, both the conventional ones, integrated over parton transverse momentum, and unintegrated transverse-momentum-dependent densities. The aim is to get a precise and correct definition of a parton density as the target expectation value of a suitable quantum mechanical operator, so that a clear connection to non-perturbative QCD is provided....