The purpose of this study was to investigate the concurrent effects of tandem length and bladder volume on dose to pelvic organs at risk (OARs) in HDR intracavitary brachytherapy treatment of cervical cancer. Twenty patients with locally advanced cervical cancer were selected for brachytherapy using Rotterdam applicators. The patients were CT scanned twice with empty and full bladder. Two treat...

We derive convexity results and related properties for the value functions of tandem queueing systems. The results for standard multi-server queues are new. For completeness we also prove and generalize existing results on tandems of controllable queues. The results can be used to compare queueing systems. This is done for systems with and without batch arrivals, and for systems with different ...

We present a solution for the following problem. Given two sequences X = x1x2 · · ·xn and Y = y1y2 · · · ym, n ≤ m, find the best scoring alignment of X ′ = X[i] vs Y over all possible pairs (k, i), for k = 1, 2, . . . and 1 ≤ i ≤ n, where X[i] is the cyclic permutation of X, X[i] is the concatenation of k complete copies of X[i] (k tandem copies), and the alignment must include all of Y and al...

The detection of tandem repeats is important in biology and medicine as it can be used for phylogenic studies and disease diagnosis. A major difficulty in identification of repeats arises from the fact that the repeat units can be either exact or imperfect, in tandem or dispersed, and of unspecified length. This paper presents results obtained by combining grey level spectrograms with a novel n...

Tandem repeat patterns are very useful for biologists as they describes a pattern that helps to determine an individual's inherited traits. Tandem repeats can be very useful in determining parentage. These repeated nucleotides play a very important role to analyse and understand the various disorders available in cancer disease. Various data mining techniques like clustering, association analys...

Although there is no genetic diversity in isolates of Mycobacterium leprae, the variance of tandem repeats in the rpoT gene was recently demonstrated. We have typed clinical isolates of M. leprae in Korea using difference of the tandem repeats in the rpoT gene. Among 69 patients, 65 Korean isolates (94.2%) demonstrated four copies of the 6 bp tandem repeat (GACATC) in the rpoT gene, and inciden...

We derive the distribution of the time-to-empty for an open tandem Jackson network assuming that, while in equilibrium at time 0, the arrival stream is suddenly shut off. The analysis is based on analogous results regarding the distribution of the time-to-empty for the corresponding closed tandem Jackson network. The results obtained are used in the analysis of a two-class tandem Jackson networ...

The performance characteristics of the Tandem-MP Ostase assay, a new microplate immunoassay for bone-specific alkaline phosphatase (bone ALP; EC 3.1.3.1) in human sera, are described. Bone ALP is bound to streptavidin-coated microwells by a single biotinylated anti-bone ALP monoclonal antibody. Antigen is detected by the addition of p-nitrophenyl phosphate. The assay is performed at room temper...

PURPOSE Cross-contamination of cell lines is a serious but often unrecognized problem. We describe the authentication of a panel of transitional cell carcinoma cell lines using the short tandem repeat profiling technique to detect cross-contamination. MATERIALS AND METHODS Genomic DNA was isolated from UM-UC-1, UM-UC-2, UM-UC-3 (ATCC), UM-UC-6, UM-UC-9, UM-UC-10, UM-UC-11, UM-UC-13, UM-UC-14,...

To develop an easy independent patient-specific quality assurance (QA) method using a benchmark plan for high-dose-rate intracavitary brachytherapy for cervix cancer, we conducted benchmark treatment planning with various sizes and combinations of tandem-ovoid and tandem-cylinder applications with 'ideal' geometry outside the patient. Two-dimensional-based treatment planning was conducted based...