نتایج جستجو برای: tamoxifen citrate

تعداد نتایج: 25062  

Journal: :Water Air and Soil Pollution 2022

Abstract The occurrence of three anticancer drugs (gemcitabine, letrozole, tamoxifen) was studied in wastewater samples from two local treatment plants (WWTPs) Finland. Studied pharmaceuticals were selected, as are potential to cause adverse effects on organisms even at low concentrations, but they seldom included the analysis emerging contaminants. concentration determined by liquid chromatogr...

Journal: :Cancer research 1995
P Carthew E A Martin I N White F De Matteis R E Edwards B M Dorman R T Heydon L L Smith

Tamoxifen administered in the diet (420 ppm) to Wistar rats (TOX:P) for only 3 months caused cumulative hepatic DNA damage as assessed by 32P-postlabeling, consistent with the proposal that tamoxifen is a genotoxic carcinogen in this species. Promotion of tumor development with phenobarbital after discontinuation of dietary tamoxifen resulted in the formation of liver carcinomas after 9 months....

2014
Kristin Dickschen Thomas Eissing Thomas Mürdter Matthias Schwab Stefan Willmann Georg Hempel

PURPOSE To overcome cytochrome P450 2D6 (CYP2D6) mediated tamoxifen resistance in postmenopausal early breast cancer, CYP2D6 phenotype-adjusted tamoxifen dosing in patients with impaired CYP2D6 metabolism and/or the application of endoxifen, the most potent tamoxifen metabolite, are alternative treatment options. To elucidate both strategies comprehensively we used a physiologically-based pharm...

Journal: :Cancer research 2013
Luduo Zhang Chun Gong Samantha L Y Lau Nan Yang Oscar G W Wong Annie N Y Cheung Janice W H Tsang Kelvin Y K Chan Ui-Soon Khoo

Gene expression profiling aimed at classifying and prognosing breast cancer has yielded signatures with little, if any, concordance. However, expression arrays used in these studies do not discriminate alternate RNA splice isoforms that vary widely in cancer and may resolve this problem. In this study, we profiled splice isoforms in a panel of tamoxifen-sensitive and -resistant cell lines, defi...

2012
Luduo Zhang Chun Gong Samantha L.Y. Lau Nan Yang Oscar G.W. Wong Annie N.Y. Cheung Janice W.H. Tsang Kelvin Y.K. Chan Ui-Soon Khoo

Gene expression profiling aimed at classifying and prognosing breast cancer has yielded signatures with little, if any, concordance. However, expression arrays used in these studies do not discriminate alternate RNA splice isoforms that vary widely in cancer and may resolve this problem. In this study, we profiled splice isoforms in a panel of tamoxifen-sensitive and -resistant cell lines, defi...

Journal: : 2021

The PI3K/Akt/mTOR is a key signaling system that binds oncogenes and various receptors to many cell functions, promotes estrogen resistance, the most frequently activated pathway in malignant neoplasm, including breast cancer (BC). About 70 % of BC hormone‑receptor positive endocrine therapy main component treatment for patients. Tamoxifen remains one basic drugs adjuvant estrogen‑positive Howe...

Journal: :Cardiovascular research 2011
Gracia El Gebeily Céline Fiset

AIMS Tamoxifen is a selective oestrogen receptor modulator widely used in the prevention and treatment of breast cancer. Women receiving long-term tamoxifen therapy do not experience cardiac arrhythmias although acute perfusion of tamoxifen has been shown to inhibit cardiac K(+) currents. This observation suggests that chronic tamoxifen treatment does not negatively modulate cardiac K(+) curren...

2016
Raie T. Bekele Ganesh Venkatraman Rong-Zong Liu Xiaoyun Tang Si Mi Matthew G. K. Benesch John R. Mackey Roseline Godbout Jonathan M. Curtis Todd P. W. McMullen David N. Brindley

Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital to understand the mechanisms that result in tamoxifen resistance. This study shows that concentratio...

Journal: :The New England journal of medicine 2004
Kevin S Hughes Lauren A Schnaper Donald Berry Constance Cirrincione Beryl McCormick Brenda Shank Judith Wheeler Lorraine A Champion Thomas J Smith Barbara L Smith Charles Shapiro Hyman B Muss Eric Winer Clifford Hudis William Wood David Sugarbaker I Craig Henderson Larry Norton

BACKGROUND In women 70 years of age or older who have early breast cancer, it is unclear whether lumpectomy plus tamoxifen is as effective as lumpectomy followed by tamoxifen plus radiation therapy. METHODS Between July 1994 and February 1999, we randomly assigned 636 women who were 70 years of age or older and who had clinical stage I (T1N0M0 according to the tumor-node-metastasis classifica...

Journal: :Circulation 2005

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