Low-calorie sweeteners are chemicals that offer the sweetness of sugar without the calories. Consumers are increasingly concerned about the quality and safety of many products present in the diet, in particular, the use of low-calorie sweeteners, flavorings, colorings, preservatives, and dietary supplements. In the present study, we evaluated the mutagenicity of the three low-calorie sweeteners...

An experimental study was performed to investigate the effects of the body angle of attack on the tail surface pressure distribution for a half body-tail combination in subsonic flow. The results show, in small deflection angle regions, that the tail deflection has the same effect on the surface pressure as the body angle of attack. However at moderate to high deflections, the flowfiled caused ...

Previous reports suggest the antiestrogen ICI 182,780 (ICI) does not cross the blood-brain barrier (BBB). However, this hypothesis has never been directly tested. In the present study, we tested whether ICI crosses the BBB, penetrates into brain and hypothalamic tissues, and affects known neuroendocrine functions in ovariectomized rats. Using HPLC with mass spectrometry, ICI (1.0 mg/kg.d, 3 d) ...

In risk management, tail risks are of crucial importance. The quality a model, which is determined by data from an unknown distribution, depends critically on the subset used to model tail. Based suitably weighted mean square error, we present method that can separate required subset. selected determine parameters model. Notably, no parameter specifications have be made apply proposed procedure...

We propose and evaluate several new scoring rules based on likelihood ratios, for comparing forecast densities in the context of VaR modelling and expected loss estimation. Our approach is motivated by the observation that existing scoring rules tend to favour fat-tailed models when compared with thin-tailed models. Rather than restricting the weight functions, we impose some restrictions on th...

A weighted recursive tree is an evolving in which vertices are assigned random vertex-weights and new connect to a predecessor with probability proportional its weight. Here, we study the maximum degree near-maximum degrees trees when almost surely bounded their distribution function satisfies mild regularity condition near zero. We able specify higher-order corrections first order growth of es...

A series of chelants (3a-s) composed of a glucosyl tail, an amino acid side chain and a dithiocarbamate group were designed, synthesized, and evaluated. By co-administering with cisplatin, 3a-s were able to decrease the accumulation of platinum in the organs, maintain the accumulation of platinum in the tumor tissues, and increase the urinary and fecal platinum, as well as increasing the voided...