Alzheimer's disease (AD) and diabetes mellitus (DM) are related to abnormal changes in enzyme activity. While acetylcholinesterase (AChE) butyrylcholinesterase (BChE) the primary targets treatment of (AD), α-glucosidase (α-Gly) α-amylase (α-Amy) enzymes known for (DM). Here, benzenesulfonamide-based thiourea thiazolidinone derivatives such as AChE, BChE, α-Gly, α-Amy inhibitors were reported. T...

takes the boundary values plus infinity on the vertical sides of the square \x\ < T T / 2 , \y\ <7r/2, and the boundary values minus infinity on the horizontal sides. This suggests the possibility of posing a boundary value problem for the minimal surface equation in which infinite data is assigned on certain boundary arcs of D. I t is a consequence of previous results of the authors (cf. [3, L...

Computer simulations constitute the basis of the design and discovery of new drugs. This approach is not only significant with regards to finding new structures, but also for selecting the molecules with the highest probability of being useful in the diagnostic process and treatment of numerous diseases. In our work, we used computational software to analyze 32 new acetylcholinesterase (AChE) i...

Recent studies have established the immunologic significance of the mixed lymphocyte interaction ( M L I ) l t h e proliferative reaction which occurs when lymphocytes from genetically disparate donors are mixed and cultured together. Even though the act ivi ty of cells in this system is assessed in terms of proliferation rather than the elaboration of a specific immunologic product, it is appa...