A study was carried out on 57 patients with chronic renal failure in a hospital in Kerman city, Islamic Republic of Iran. Blood samples were taken before and after haemodialysis to measure blood urea nitrogen and serum creatinine, triiodothyronine (T3) and thyroxine (T4) levels. Findings revealed that before dialysis T4 in 11 cases and T3 in 29 cases were lower than the normal range, but after ...

We evaluated the effects of temperature and humidity on thyroid hormones (T4, T3) and thyrotropin (TSH) measured in blood spots dried on filter paper. RIAs for T4 and T3 blood spots were optimized to measure these analytes over the neonatal and euthyroid adult reference intervals. Sensitivities of the T3 and T4 assays were 0.5 and 10 nmol/L, respectively. A blood-spot immunoradiometric assay fo...

The aim of this study was to evaluate total iodine, triiodothyronine (T3) and thyroxine (T4) status in the blood serum of Holstein cows on six farms in central Iran. Total iodine, T3 and T4 concentrations were measured in 90 blood serum samples (15 per farm). Mean concentrations of total iodine (38.80 ± 1.52 µg/l) and T3 (1.57 ± 0.10 nmol/l) were lower but the mean concentration of T4 (45.60 ± ...

Studies on glaucous gulls (Larus hyperboreus) breeding in the Barents Sea have reported that high blood levels of halogenated organic contaminants in this species might cause reproductive, behavioral, and developmental stress. However, potential endocrine system modulation caused by contaminant exposure has yet not been reported in this Arctic apical predator. In this present study we aimed to ...

Background: Stress has different effects on the body and endocrine system. Objectives: The main aim of this study is to determine the effects of immobilization stress and Aloe vera extract on levels of TSH, T3 or T4 in male rats. Materials and Methods: In this experimental study, 90 male Wistar rats were randomly divided into 9 groups of control, receiving normal saline, receiving Aloe vera ext...

Thyroid hormones (THs) are essential for fetal and post-natal nervous system development and also play an important role in the maintenance of adult brain function. Of the two major THs, T4 (3,5,3',5'-tetraiodo-l-thyronine) is classically viewed as an pro-hormone that must be converted to T3 (3,5,3'-tri-iodo-l-thyronine) via tissue-level deiodinases for biological activity. THs primarily mediat...

Thyroid functions were studied in 11 patients with subacute thyroiditis accompanied by signs and symptoms of hyperthyroidism, and were compared with 13 patients with untreated thyrotoxicosis in which serum T4 was elevated to the identical level. Serum T3 was also elevated in subacute thyroiditis but to a significantly lower extent than in thyrotoxicosis. Therefore the ratio of T4/T3 was signifi...

Transport of thyroid hormone across the cell membrane is required for its action and metabolism. Recently, a T-type amino acid transporter was cloned which transports aromatic amino acids but not iodothyronines. This transporter belongs to the monocarboxylate transporter (MCT) family and is most homologous with MCT8 (SLC16A2). Therefore, we cloned rat MCT8 and tested it for thyroid hormone tran...

Various methods are used to determine plasma thyroid hormones concentrations in medical diagnostic laboratories; but, some of them influence the results for thyroid hormone levels in domestic animals. The aim of this study was to compare the levels of two predominant plasma thyroid hormones using electrochemiluminescence immunoassay (ECLIA) and radioimmunoassay (RIA) methods in sheep. Blood sam...

UNLABELLED BACKGROUND AND RATIONALE FOR THE STUDY: To investigate thyroid function in patients with acute-on-chronic liver failure (ACLF) caused by hepatitis B virus infection and to determine whether thyroid hormone levels can be used as prognostic markers for assessing severity and prognosis of ACLF patients. We enrolled 75 patients with ACLF and70 patients with chronic hepatitis B (CHB). Con...