STUDY DESIGN Retrospective review of prospective multicenter database. OBJECTIVE Use predictive modeling to identify patient characteristics, radiographic, and surgical variables that predict reaching an outcome threshold of suboptimal cervical alignment after adult spinal deformity (ASD) surgery. SUMMARY OF BACKGROUND DATA Cervical deformity (CD) after ASD correction has been defined with ...

OBJECTIVE To examine the effect of a topical cream consisting of cetylated fatty acids on functional performance in patients diagnosed with osteoarthritis (OA) of one or both knees. METHODS Forty patients diagnosed with knee OA were randomly assigned to one of 2 topical treatment groups: (1) cetylated fatty acid (CFA) (n = 20; age 62.7 +/- 11.7 yrs); or (2) placebo group (n = 20; age 64.6 +/-...

Few studies on the alterations in endocrine function during African trypanosomiasis in man have been reported in the literature, and these concem mainly disorders observed at the gonadotropic axis level (RIDET, 1953; EMEH & NDUKA, 1983; HUBLART er al., 1987). To our knowledge, the thyroid hormone balance has not been investigated, although certain clinical manifestations may be suggestive of th...

BACKGROUND Real time non-invasive determination of stroke volume (SV) is important to astronaut orthostatic testing. We compared simultaneous estimates of SV calculated from peripheral pulse waveforms with a more conventional non-invasive technique. METHODS Ten men and nine women completed 12-min protocols. The relative change (% delta) in beat-to-beat SV was estimated non-invasively from cha...

Diabetes mellitus leads to increased Advanced Glycation End Products (AGE) production, which has been associated with secondary diabetic complications. Type 1 diabetic patients undergoing pancreas-kidney transplantation (SPKT) can restore normoglycemia and renal function, eventually decreasing AGE accumulation. We aimed to prospectively study AGE evolution after SPKT. Circulating AGE were asses...

Neonatal changes in plasma free and total iodothyronines, cortisol, glucose and urea levels have been studied in 8 control (birthweight greater than or equal to 2.5 kg) and 16 hypotrophic lambs (birthweight less than 2.5 kg) receiving limited amounts of colostrum during the first 36 h of life and then fed ad libitum. During the period of colostrum feeding, plasma glucose levels were low in both...

OBJECTIVE To test whether annual screening with transvaginal ultrasonography and CA 125 reduces ovarian cancer mortality. METHODS Data from the first four annual screens, denoted T0-T3, are reported. A CA 125 value at or above 35 units/mL or an abnormality on transvaginal ultrasonography was considered a positive screen. Diagnostic follow-up of positive screens was performed at the discretion...

Thyroid hormone, 3,3',5-triiodo-l-thyronine (T3), mediates several physiological processes, including embryonic development, cellular differentiation and cell proliferation, via binding to its nuclear thyroid receptors (TR). Previous microarray and Chromatin immunoprecipitation (ChIP)-on-ChIP analyses have revealed that interferon-stimulated gene 20 kDa (ISG20), an exoribonuclease involved in t...

To examine retrospectively the prognostic significance of TP53 immunoreactivity for both tumor response and patient survival in 83 patients with nonmetastatic muscle-invasive bladder cancer treated with a single transurethral resection (TUR) of tumor and combined cisplatin-based systemic chemotherapy followed by repeat TUR, paraffin-embedded sections of a bladder tumor obtained at TUR before ch...