OBJECTIVES The goal of this work was to investigate iron deposition in the basal ganglia and thalamus in symptomatic and asymptomatic leucine-rich repeat kinase 2 (LRRK2) and Parkin-associated Parkinson's disease (PD), using R2* relaxometry rate. METHODS Twenty subjects with genetic PD (four symptomatic and two asymptomatic Parkin subjects, nine symptomatic and five asymptomatic LRRK2 subject...

Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the striatum. The main striatal output structure, the globus pallidus, strongly accumulates metalloprotein-bound iron, which was recently shown to inf...

OBJECTIVES The aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI). METHODS Forty-two MCI patients and 77 healthy controls (HC) underwent T1/T2* relaxometry as well as Magnetization Transfer (MT) MRI. Between-groups comparisons in MRI metrics were performed...

Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a paramagnetic hepatobiliary magnetic resonance (MR) contrast agent. Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. In this paper we compare the diagn...

Abstract PURPOSE The utility of post-contrast magnetic resonance fingerprinting (MRF) for brain tumor assessment has not been assessed. aim this work is to report differences in MRF-derived delta-relaxometry metrics between metastases and glioblastoma, offering a new strategy differentiation. METHODS Post- pre-contrast MRF (T1, T2 proton density maps) were acquired from 29 patients (14 (Met), 1...

INTRODUCTION Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based lesion pathology in cognition and disability. METHODS 36 relapsing-remitting MS subjects and 18 healthy controls underwent neurological, cog...

Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with recombinant human epidermal growth factor (SPION-EGF) were studied as a potential agent for magnetic resonance imaging contrast enhancement of malignant brain tumors. Synthesized conjugates were characterized by transmission electron microscopy, dynamic light scattering, and nuclear magnetic resonance relaxometry. The interacti...

Understanding the need Quantitative vs Qualitative MRI data: The vast majority of common clinical MRI protocols rely on qualitative images reflecting the weighted effect of different tissue parameters. These contrast parameters include relaxation times, principally T1, T2 and T2*, as well as structural or functional quantities such as diffusion and blood flow. The absolute level of the signal v...

Background Quantitative MR relaxometry techniques are increasingly used in cardiac MR applications, e.g. MOLLI for high resolution T1 mapping. To use these techniques in the clinic, we must understand how to make comparable measurements across vendor systems and software versions and compare results across sites. A standardized phantom used for regular quality control is one approach. The Bioma...

There is little experimental in vivo data on how differences in seizure duration in experimental status epilepticus influence metabolic injury. This is of interest given that in humans, status duration is a factor that influences the probability of subsequent development of epilepsy. This question is studied using 7-T magnetic resonance (MR) spectroscopy, T2 relaxometry in the incremented kaina...