The overall objective of this study is to non-invasively image and assess tumor targeting and retention of directly labeled T-lymphocytes following their adoptive transfer in mice. T-lymphocytes obtained from draining lymph nodes of 4T1 (murine breast cancer cell) sensitized BALB/C mice were activated in-vitro with Bryostatin/Ionomycin for 18 hours, and were grown in the presence of Interleukin...

To examine the effects of exposure to manganese (Mn) on the cellular and humoral immune system in men, T lymphocyte subpopulations, B (CD19+) lymphocytes, natural killer (NK) cells, and serum immunoglobulins (i.e., IgG, IgA and IgM) together with total T (CD3+) lymphocytes and total lymphocytes were measured in blood samples from 21 welders mainly exposed to Mn fume with blood Mn (BMn) concentr...

Introduction: Along with the increased use of cardiac imaging at clinics there is increased attention to the potential risks related to the methods used like magnetic resonance (MR) and it cannot be ruled out that MR can alter DNA structure. The aim of this review is to assess the impact of routine cardiac magnetic resonance (CMR) scanning on DNA damages in human T lymphocytes....

PURPOSE The expression of FasR, Fas-L and Bcl-2 on CD4+ and CD8+ T lymphocytes subpopulations from the cord blood were assayed. The results in blood from boys and girls were analyses separately and compared. MATERIAL AND METHODS Twenty four full-term newborns: 13 females and 11 males were included into the study. Blood from the umbilical vein was collected immediately after cutting the umbili...

Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, is histologically characterized by atypical T lymphocytes with cerebriform nuclei that infiltrate the epidermis. Alope

BACKGROUND The chemokine eotaxin is produced at sites of allergic inflammation, binds selectively to the chemokine receptor CCR3 and attracts eosinophil and basophil leukocytes, which express high numbers of this receptor. Responses of T lymphocytes to eotaxin have not been reported so far. We have investigated the expression of CCR3 in T lymphocytes and analysed the properties and in vivo dist...

the aim of this study was to evaluate the immune system and lymphocyte function in 41 iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. the patients consisted of 20 splenectomized and 21 non-splenectomized patients. they were treated with desferal, and had received repeated blood transfusion. laboratory investigations included measurement of total t lymphocytes, a...

The aims of this study were first, to assess whether or not immunoglobulin secretion from human gut mucosal B lymphocytes can be modified by T lymphocytes, and second whether human gut mucosal T lymphocytes are capable of regulating mucosal B lymphocyte function. T and B lymphocyte enriched cell populations were isolated from gut mucosa and co-cultured in varying proportions. Addition of T lymp...