OBJECTIVE To determine the serum levels of interferon alpha in childhood-onset systemic lupus erythematosus patients, their first-degree relatives and healthy controls and to evaluate the associations between serum interferon alpha and disease activity, laboratory findings and treatment features. METHODS We screened consecutive childhood-onset systemic lupus erythematosus patients in a longit...

Although thalidomide is a U.S. Food and Drug Admistration (FDA) approved medication for erythema nodosum leprosum and multiple myeloma, it has many off-label uses, including for discoid lupus erythematosus (DLE), Behçet's disease, apththous ulcers in HIV patients, and prurigo nodularis. Herein, we present a patient with an overlap of discoid lupus erythematosus and lichen planus who was success...

Almost a century ago, the relationship of sarcoid infiltrations of the skin and granulomatous changes in other organs was recognised. Schaumann, in 1914, proposed that lupus pernio (fig. 1a–c) could be a manifestation of a generalised disease. Later on, a variety of skin manifestations have been described to occur more or less frequently. Lupus pernio indicates an unfavourable prognosis, wherea...

The diagnostic significance of anti-double-stranded deoxyribonucleic acid (anti-dsDNA) determination was evaluated in a prospective manner from 1974 to 1982 in a group of 441 patients without systemic lupus erythematosus whose sera were found to contain antibodies to dsDNA on routine screening (Farr assay). Within one year 69% (304) of these patients fulfilled the preliminary American Rheumatis...

To cite: Chen K-L, Chien M-M, Chen C-Y, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2016-216037 DESCRIPTION A male neonate was born by caesarean section due to placental abruption at 34 weeks of gestation. Gestational diabetes and polyhydramnios were noted during pregnancy. There was no premature rupture of membrane. At birth, many thin erythematous fi...

UNLABELLED INTRODUCTION The occurrence of systemic lupus erythematosus has been only rarely reported in patients with sickle-cell disease. CASE PRESENTATION We describe the case of a 23-year-old North-African woman with sickle-cell disease and systemic lupus erythematosus, and discuss the pointers to the diagnosis of this combination of conditions and also present a review of literature. T...

anti malaria agents including chloroquine and hydroxichloroquine are commonly used for rheumatic diseases e.g. systemic erythematous lupus or rheumatoid arthritis. one of the most important systemic side effects of these agents is ocular side effects (chloroquine toxicity retinopathy). regarding to importance of early detection of this toxicity, the patients who take these drugs should be evalu...

A 24-year-old woman was referred to our department for high fever, scattered erythema on her face, and altered mentation. Laboratory findings showed pancytopenia, positive anti-nuclear antibody, positive anti-Sm antibody, and urine protein. Immunoglobulin deposit was observed in a facial skin biopsy. When all of the symptoms were considered, systemic lupus erythematosus (SLE) with central nervo...

Objective(s): Systemic lupus erythematosus (SLE) is an autoimmune disease with a wide range of clinical manifestations. Cognitive dysfunction is one of the manifestations that could present prior to the emergence of any other neuropsychiatric involvements in SLE. Cognitive dysfunction is a subtle condition occurring with ahigh frequency. However, there is no data on the correlation of cognitive...