The cDNA of the mineralocorticoid receptor (MR) was cloned 30 years ago, in 1987. At that time, spirolactone, the first generation of synthetic steroid-based MR antagonists (MRAs), which was identified in preclinical in vivo models, had already been in clinical use for 30 years. Subsequent decades of research and development by Searle & Co., Ciba-Geigy, Roussel Uclaf and Schering AG toward iden...

Fast growing data sets with a very high number of attributes become a common situation in social, industry and scientific areas. A meaningful analysis of these data sets requires sophisticated data mining techniques as projected clustering that are able to deal with such complex data. In this work, we investigate solutions for extending the state-of-theart projected clustering algorithm P3C for...

The present study focusses on the damping force control of shear mode magnetorheological (MR) damper for seismic mitigations. Therefore, the semi-active MR damper which can control the vibration is analyzed both experimentally and numerically. Carbonyl iron is used as the magnetic particle and Castrol Magnetec oil as carrier fluid throughout the study. MR damper is designed and fabricated, and ...

Bias field causes considerable difficulty in the quantitative analysis of brain magnetic resonance (MR) images. Image registration is a necessary pre-processing step before quantitative analysis of brain MR data. A novel variational optical flow approach for image registration is proposed in this paper. The advantages of our method are as follows. First, we coupled bias correction and optical f...

In this paper, we present the region based hidden Markov random field model (RBHMRF), which encodes the characteristics of different brain regions into a probabilistic framework for brain MR image segmentation. The recently proposed TV+L model is used for region extraction. By utilizing different spatial characteristics in different brain regions, the RMHMRF model performs beyond the current st...

Chromosomal genes encoding the MS and Gal-Gal binding properties have been cloned into separate recombinants and their respective pili characterized. Hapten inhibition of hemagglutination with synthetic carbohydrate receptor analogues and carbohydrate-adsorbed latex agglutination studies indicate that Gal-Gal and MS pili collectively exhibit the binding properties of the parent strain. MS pili ...

Tannins have a number ofdetrimental biological effects and these include interference with normal growth and metabolism if they are present in the feed of various animals. Proline-rich proteins (PRPs) in saliva have been shown to provide protection against tannin, but little is known about the mechanism of protection and interaction of other salivary proteins with tannin. To identify tannin-bin...

This paper presents a strategy for the segmentation of brain from volumetric MR images which integrates 3D segmentation and 3D registration processes. The segmentation process is based on the level set formalism. A closed 3D surface propagates towards the desired boundaries through the iterative evolution of a 4D implicit function. In this work, the propagation relies on a robust evolution mode...

Extraction of the mid-sagittal plane (MSP) is a key step for brain image registration and asymmetry analysis. We present a fast MSP extraction method for 3D MR images, based on automatic segmentation of the brain and on heuristic maximization of the cerebro-spinal fluid within the MSP. The method is robust to severe anatomical asymmetries between the hemispheres, caused by surgical procedures a...

Metallothionein (MT) genes contain multiple metal regulatory elements (MREs) that are responsible for metal induction. A protein blotting procedure and a synthetic oligonucleotide have been used to identify nuclear factors interacting with a MRE (MREd) of the mouse MT-1 gene. We report the specific binding of the probe to a protein of apparent Mr 108,000 (p108). The specificity of the interacti...