نتایج جستجو برای: synapse
تعداد نتایج: 15136 فیلتر نتایج به سال:
It is the purpose of this paper to attempt the development of a theory of association in terms of the temporal functions of the nervous impulse. The most orthodox theory of association perhaps is that involving some form of resistance to conduction of the nervous impulse at the synapse. It assumes that the neural changes taking place in learning involve breaking down the resistance of the limit...
Experimental data have shown that synapses are heterogeneous: different synapses respond with different sequences of amplitudes of postsynaptic responses to the same spike train. Neither the role of synaptic dynamics itself nor the role of the heterogeneity of synaptic dynamics for computations in neural circuits is well understood. We present in this article methods that make it feasible to co...
Reconstructing neuronal circuits at the level of synapses is a central problem in neuroscience and becoming a focus of the emerging field of connectomics. To date, electron microscopy (EM) is the most proven technique for identifying and quantifying synaptic connections. As advances in EM make acquiring larger datasets possible, subsequent manual synapse identification (i.e., proofreading) for ...
www.sciencemag.org (this information is current as of April 14, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/281/5377/619a version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/281/5377/619a#otherarticles ,...
Normal brain function requires balanced development of excitatory and inhibitory synapses. An imbalance in synaptic transmission underlies many brain disorders such as epilepsy, schizophrenia, and autism. Compared with excitatory synapses, relatively little is known about the molecular control of inhibitory synapse development. We used a genetic approach in mice to identify the Ig superfamily m...
Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing eviden...
ii Acknowledgments I would like to take this time to thank my wonderful friends, old and new, who have made these last four years at Brandeis truly memorable. I'm grateful that you were able to pull me out of studying and lab work long enough for me to take a break from it all and enjoy life. I'll always cherish the moments that we spent together. In terms of my development as a scientist, I wo...
A number of experiments have reported that neurons in primary visual cortex can adapt in a stimulus-dependent manner. Synaptic depression is a plausible mechanism for this type of adaptation because its synapse speci"city allows modi"cation of particular inputs while allowing others to remain una!ected. Furthermore, a form of synaptic depression measured in slice experiments sets in and recover...
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