Lineage-tracing experiments have indicated that some premigratory neural crest cells (NCCs) are pleuripotent, generating sensory and sympathetic neurons and their associated glia. Using an inducible Cre recombinase-based fate mapping system, we have permanently marked a subpopulation of NCCs that expresses Ngn2, a bHLH transcription factor required for sensory neurogenesis, and compared its fat...

The possible involvement of the local angiotensin system in ganglionic functions was investigated in the canine cardiac sympathetic ganglia. Positive chronotropic responses to preganglionic stellate stimulation at high frequencies, after intravenous administration of pentolinium plus atropine, were inhibited by the nonpeptide angiotensin AT(1) receptor antagonist forasartan or the angiotensin I...

BACKGROUND AND AIM A neuronal pathway participates in the development of portal hypertension: blockade of afferent sensory nerves in portal vein ligated (PVL) rats simultaneously prevents brain cardiovascular regularory nuclei activation, neuromodulator overexpression in superior mesenteric ganglia, sympathetic atrophy of mesenteric innervation and hemodynamic alterations. Here we investigated ...

Oral Absorption and Disposition Kinetics of Lidocaine Hydrochloride in Dogs. R. N. BOYES, H. J. ADAMS AND B. R. DUCE 1 Maternal and Fetal Distribution of H3-Dihydromorphine in the Tolerant and Nontolerant Rat. S. Y. YEH AND L. A. WOODS 9 Retention of Inhaled Acetaldehyde in Man. JOHN L. EGLE, JR 14 Efflux of Chiorpromazine and Trifluoperazine from the Rat Brain. P. F. SPANO, N. H. NEFF, E. MACK...

INThODUCTION Previous experiments have given evidence that mouse Sarcomas 37 and 180 produce an agent which promotes the growth of spinal ganglia (1) and of sympathetic ganglia (l@) in the chick embryo. This effect was first observed in experi ments in which small pieces of tumor were im planted in the body wall of 3-day embryos, where they grew vigorously. Later, the same effects were obtained...

Transmission of neuronal activity was assessed by recording preganglionic and postganglionic compound action potentials in superior cervical ganglia isolated from adult spontaneously hypertensive rats (SHR), Wistar-Kyoto (WKY) rats, and Wistar rats as well as young SHR and WKY rats to determine if previously observed alterations of membrane excitability, synaptic transmission, or both, have an ...

The virus of poliomyelitis is neurotropic, and localizes, and probably is capable of multiplying in the extramedullary parenchymatous nervous organs. It has been demonstrated by inoculation tests in the intervertebral, Gasserian, and abdominal sympathetic ganglia. All the ganglia show histological lesions, more or less severe, similar to those of the spinal cord and brain. The severest occur in...

In rhesus and cynomolgus monkeys without signs or symptoms of poliomyelitis, a comparison of the incidence, numbers, size, and character of lesions in certain peripheral ganglia (gasserian, nodose, superior cervical sympathetic, and celiac) was made between 9 "new" animals sacrificed 1 to 3 days after arrival in a laboratory devoted exclusively to poliomyelitis research, and 17 "old" animals ho...