Petroleum ether, chloroform and methanol extracts of A. maciverae were studied in vitro and in vivo for activity against Trypanosoma brucei brucei in Swiss albino mice. Thereafter, the chloroform extract which showed the highest activity in both in vitro and in vivo assessments was subjected to bioassay-guided fractionation. The crude extracts and the fractions of the chloroform extract of A. m...

Rutin is the bioactive flavanoid isolated from the straw part of Triticum aestivum and possess various pharmacological applications. The aim of this study is to evaluate the chemopreventive potential of rutin in an experimental skin carcinogenesis mice model system. Skin tumor was induced by topical application of 7,12-dimethyl benz(a) anthracene (DMBA) and promoted by croton oil in Swiss albin...

Present study was undertaken to determine the median lethal dose (LD50) of β-cyfluthrin (β-cyf), a synthetic (type II) pyrethroid pesticide in male and female Swiss albino mice. The calculation of LD 50 is an initial screening step in the assessment and evaluation of the toxic characteristic of a chemical substance. The selected single doses of β-cyfluthrin based on the pilot study were 200, 22...

The present study deals with the maternotoxicity of leachate from Combined Effluent Treatment Plant CETP Pali, Rajasthan, India when administered to Swiss albino mice during various stages of reproductive cycle. An attempt has been made to study the maternotoxic effect of sludge leachate obtained from CETP, Pali which receives effluent exclusively from textile and dyeing industries located at P...

Diabetes mellitus is a metabolic disorder and affects nearly 10% of the population every year. The aim of present study was to investigate the histological changes in diabetic Induced Swiss albino mice, Mus norvegicus albinus on exposure to 1Deoxynojirimycin. 1-Deoxynojirimycin is known to be a potent antidiabetic compound. The study was conducted on mice Swiss albino male mice, the animals wer...

Caesalpinia sappan L. (Caesalpiniaceae) is a medicinal plant which is used as a thirst quencher in southern part of India especially in Kerala. The present study was conducted to scientifically evaluate the effects of extracts of Caesalpinia sappan on phagocytic function of macrophages. In vivo effect of aqueous, ethanol and hexane extract of the plant at two doses (10mg/kg body weight and 25mg...

BACKGROUND Doxorubicin is one of the most active cytotoxic agents in current use. It has proven efficacy in various malignancies either alone or combined with other cytocidal agents. The clinical usefulness of the anthracycline drug has been precluded by cardiac toxicity. Many therapeutic interventions have been attempted to improve the therapeutic benefits of the drug. Few, however, have been ...

Ziziphus mauritiana (Lamk.) is a fruit tree that has folkloric implications against many ailments and diseases. In the present study, anticancer potential of seed extract of Ziziphus mauritiana in vitro against different cell lines (HL-60, Molt-4, HeLa, and normal cell line HGF) by MTT assay as well as in vivo against Ehrich ascites carcinoma bearing Swiss albino mice was investigated. The extr...

The present study was undertaken to evaluate the medicinal properties of Hibiscus rosa sinensis on male mice. For this Swiss albino mice were orally administered Hibiscus rosa sinensis (500 mg/kg of body weight) and effect of the treatment on, reproductive organ cholesterol level and glucose level. Recovery study was also carried out. The treatment caused reduction in the weight of testis, epid...