An ultra-sensitive and highly specific electrical double layer (EDL) modulated biosensor, using nanoporous flexible substrates for wearable diagnostics is demonstrated with the detection of the stress biomarker cortisol in synthetic and human sweat. Zinc oxide thin film was used as active region in contact with the liquid i.e. synthetic and human sweat containing the biomolecules. Cortisol dete...

Applying the sweat-test as the first choice of test when a diagnosis of cystic fibrosis is suspected is still common practice and advisable. Since the cloning of the CFTR gene more than 400 different cystic fibrosis (CF) mutations have already been identified. The use of CF mutation analysis for diagnostic purposes in CF has therefore remained elusive so far. It is advised to perform sweat-test...

Knowledge as to the composition of sweat is as yet fragmentary and many points are subject to dispute. Reasons for this are numerous, some of the more obvious being the difficulty of making satisfactory collections, variation in composition of sweat elaborated by different regions of the body, and the fact that exploratory work cannot be done on animals. The subject assumes considerable importa...

OBJECTIVES To examine the results of thermoregulatory sweat testing in patients with erythromelalgia and to compare them with the results of other neurophysiologic tests of small-fiber nerve function. DESIGN Retrospective study. SETTING Tertiary referral center. PATIENTS Thirty-two consecutive patients with erythromelalgia who had thermoregulatory sweat testing in addition to vascular and...

Antimicrobial peptides (AMPs) are effector molecules of innate immunity. Dermcidin (DCD), a recently discovered AMP with broad-spectrum activity, is produced constitutively by the eccrine sweat glands and secreted into sweat. In this study, we investigated the proteolytic processing, site-specific expression, and stability of DCD peptides in eccrine sweat. Using surface-enhanced laser desorptio...

Sweat gland epithelial cells (SGECs) have been identified as essential for the regeneration of sweat glands and for the construction of skin substitutes containing skin appendages. Consequently, the isolation, culture and phenotypic characterization of SGECs are of paramount importance. In the present study study, human sweat glands were isolated by pipetting under a phase contrast microscope f...

Hyperhidrosis is an idiopathic condition of exaggerated sweat production resulting in dramatic impairments of daily activities, social interactions and occupational activities. The aim of the present study was to evaluate correlation between a subjective (Dermatology Life Quality Index) and an objective (Minor test) criterion and to assess difference in their levels over time in patients affect...

BACKGROUND Chromhidrosis means production of coloured sweat. CASE CHARACTERISTICS A toddler who presented with colored sweat was diagnosed to have chromhidrosis based on skin biopsy. No treatment was attempted considering the young age. OUTCOME Parents were counselled about the benign nature of this disorder. MESSAGE Identification of causes of colored sweat requires appropriate investiga...

Sweat is well known to vary in composition and amount over different areas of the body. A wide range of values is found in sweat from corresponding areas in different individuals, and in our experience even from the same subject at different times under apparently the same conditions. The extent of this range is in itself a matter of considerable interest and invites fuller investigation of the...

This observational study was designed to determine whether football players with a history of heat cramps have elevated fluid and sodium losses during training. During a "two-a-day" training camp, five Division I collegiate football players (20.2 +/- 1.6 y, 113 +/- 20 kg) with history of heat cramps (C) were matched (weight, age, race and position) with a cohort of teammates (19.6 +/- 0.6 y, 11...