an oral suspension could a suitable dosage form for the geriatric patients. the calcium alginate coated ion exchange resinate of propranolol hydrochloride were prepared using amberlite ir-120 by solvent evaporation. microcapsules of propranolol hydrochloride resinate were prepared by solvent evaporation technique,the suspensions were prepared by using deionised water as the vehicle. methyl cell...

Growth factors are a class of cytokines that stimulate cell growth and are widely used in clinical practice, such as wound healing, revascularization, bone repair, and nervous system disease. However, free growth factors have a short half-life and are instable in vivo. Therefore, the search of excellent carriers to enhance sustained release of growth factors in vivo has become an area of intens...

Purpose: Enalapril maleate (EPM), was used for hypertension and congestive heart failure. In this way, an innovative delivery system with mPEG–PCL was synthesized and the release profile of the EPM from the drug-loaded polymersomes was evaluated. Methods: Di-block methoxy)-poly (ethylene glycol) - Poly (caprolactone) (mPEG-PCL) copolymers were synthesized and used to prepare of polymersom...

      The first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using PEG 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. The second objective was to apply the modified solvent method for preparation of sustained re...

For controlled release and targeted delivery of curcumin in an aqueous medium a method of encapsulating curcumin and magnetic nanoparticles inside porous silica matrix has been developed. Curcumin and superparamagnetic nanoparticles are loaded inside porous silica in a single process. The graphic shows the TEM image of microtomed sample of Fe(3)O(4) particles surrounded by a silica matrix.

A simple spectrophotometric method for determination of glucosamine release from sustained release (SR) hydrophilic matrix tablet based on reaction with ninhydrin is developed, optimized and validated. The purple color (Ruhemann purple) resulted from the reaction was stabilized and measured at 570 nm. The method optimization was essential as many procedural parameters influenced the accuracy of...

Controlled release studies of DNA from polymers have been limited, with most studies concentrating on microsphere formulations. This report details a study done on the release and transfection efficiencies of pDNA-lipofectamine complex (lipoplex), from selected polymeric films in which it was dispersed; the release and transfection efficiency was compared with that of naked pDNA. A biodegradabl...

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The bioavailability of a generic diclofenac sodium sustained release tablet preparation (Zolterol, SR) was compared with the innovator product, Voltaren, SR. Twelve healthy adult male volunteers participated in the study, which was conducted according to a randomized, two-way crossover design with a wash out period of one week. The bioavailability of diclofenac was compared using the parameters...