The objective of this study was to synthesize and characterize particles as a drug-delivery platform for gliomas, a highly advanced and invasive stage of brain tumor with poor prognosis. Poly(aminoethyl methacrylate-co-methyl methacrylate) particles were prepared by suspension polymerization and poly(aminoethyl methacrylate-co-poly(ethylene glycol) methacrylate) particles were prepared by emuls...

A hypercrosslinked styrenic polymer with an enhanced proportion of mesopores in the range 2-20 nm has been developed. The principle of the synthesis consists of the suspension polymerization of divinylbenzene (or copolymerization of styrene with divinylbenzene) in the presence of a porogen that is a theta-solvent for polystyrene. On the scale of thermodynamic affinity, theta-solvents occupy a b...

A novel high throughput method for synthesis and screening of customized protein-resistant surfaces was developed. This method is an inexpensive, fast, reproducible and scalable approach to synthesize and screen protein-resistant surfaces appropriate for a specific feed. The method is illustrated here by combining a high throughput platform (HTP) approach together with our patented photo-induce...

Cell migration is a crucial event that occurs during many processes including wound healing, angiogenesis, development and metastasis. Although migratory phenotypes and factors that promote migration vary greatly among cell types, the basic mechanism that drives cell migration in all cells is polarized actin polymerization (Pollard and Borisy, 2003). This process is initiated by chemotactic fac...

SUPERCRITICAL CO2 BY AN ELECTRON POOR NI(II) COMPLEX Damien Guironnet and Stefan Mecking* Chair of Chemical Materials Science, Department of Chemistry, University of Konstanz, Germany. Introduction Late transition metal catalysts for polymerization of olefins have been studied intensely. Due to their functional group tolerance, polymerizations can be carried out in oxygenated reaction media, am...

This paper presents the results of a study process hydrogenation 1-hexene in ethanol and phenylacetylene hexanewater suspension over multicomponent nickel skeleton catalysts It was demonstrated that activity is substantially dependent on nature additives introduced into bearing alloy. Introduction Cu, Pb Ta leads to an increase (W=196-295cm 3 /min-gNi). The major mechanism effect emulsion compo...

We have used a modified, dual pipette assay to quantify the strength of cadherin-dependent cell-cell adhesion. The force required to separate E-cadherin-expressing paired cells in suspension was measured as an index of intercellular adhesion. Separation force depended on the homophilic interaction of functional cadherins at the cell surface, increasing with the duration of contact and with cadh...

We have isolated and characterized Dictyostelium discoideum mutants with conditional defects in phagocytosis. Under suspension conditions, the mutants exhibited dramatic reductions in the uptake of bacteria and polystyrene latex beads. The initial binding of these ligands was unaffected, however, indicating that the defect was not in a plasma membrane receptor: Because of the phagocytosis defec...

Affinity cross-linking of the plasma membrane fraction to an (125)I-labeled chitin oligosaccharide led to the identification and characterization of an 85-kD, chitin binding protein in plasma membrane-enriched fractions from both suspension-cultured soybean cells and root tissue. Inhibition analysis indicated a binding preference for larger (i.e. degrees of polymerization = 8) N-acetylated chit...