Pyoderma Gangrenosum is a rare neutrophilic dermatosis of skin and subcutaneous tissue characterized by a painful and progressive necrotizing process. The management of pyoderma gangrenosum often requires systemic drug therapy, such as corticosteroids, sulfones or immunosuppressants, either alone or in combination. Several reports in the literature document the successful treatment of pyoderma ...

Supporting Information General methods. Infrared spectra were recorded on a Nicolet AVATAR-360 spectrometer. H NMR and C NMR spectra were recorded at Bruker AM-300 instruments. Low resolution mass spectra (m/z) were recorded on HP5989A. High-resolution mass spectra were recorded on Concept 1H or MALDI/DHB. Microanalyses were performed using a Elemantar Vario EL. All reaction flasks were dried b...

Dipolar addition of cyclic azomethine imines with cyclic vinyl sulfones gave rise to functionalized tricycles that exhibited fluxional behavior in solution at room temperature. The scope of the synthetic methodology was explored, and the origin of the fluxional behavior was probed by NMR methods together with DFT calculations. This behavior was ultimately attributed to stereochemical inversion ...

 The synthesis in water of new sulfone derivatives under microwave irradiation is described. This eco-friendly process leads to the expected products in good yields by reaction of various substituted sulfinates (commercially available or obtained by reduction of the corresponding sulfonyl chlorides) with 4-chloromethyl-2-methyl-5-nitro-1,3-thiazole. In order to evaluate the antiproliferative ef...

Abstract-This review article defines suicide substrates as a class of irreversible inactivators of specific target enzymes where the target enzyme participates in its own destruction by catalytic unmasking of a latent functional group at some stage in the catalytic cycle of the enzyme. Criteria for evaluation of suicide substrates are presented. Then, examples of the various types of latent fun...

4H-1,4-Benzothiazines and its derivatives are potential pharmacologically and industrially useful agents. They were prepared by condensation followed by oxidative cyclization of 2-amino-4,6-dimethylbenzenethiol with varied βdiketones/β-ketoesters in dimethyl sulfoxide. On refluxing with H2O2 in glacial acetic acid, the substituted 4H-1,4Benzothiazines yielded 4H-1,4-Benzothiazine-1,1-dioxides (...